Does Bosentan Protect Diabetic Brain Alterations in Rats? The Role of Endothelin-1 in the Diabetic Brain

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dc.contributor.authorDemir, Recep
dc.contributor.authorCadirci, Elif
dc.contributor.authorAkpinar, Erol
dc.contributor.authorCayir, Yasemin
dc.contributor.authorAtmaca, Hasan Tarik
dc.contributor.authorUn, Harun
dc.contributor.authorDemir, Ilknur
dc.date.accessioned2020-06-25T18:13:32Z
dc.date.available2020-06-25T18:13:32Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionCayir, Yasemin/0000-0001-9133-5460; UN, Harun/0000-0003-1772-282X; Yayla, Muhammed/0000-0002-0659-3084; ATMACA, HASAN TARIK/0000-0001-8379-4114
dc.description.abstractDiabetes mellitus (DM) is a major problem all over the world, affecting more people in recent years. Individuals with diabetes are more prone to disease than non-diabetics, especially vascular complications. The aim of this study was to examine the roles of the endothelin (ET)-1 in brain damage formed in a streptozocin (STZ)-induced diabetes model, and the effect of bosentan, which is the non-specific ET1 receptor blocker in the prevention of the diabetes-induced brain damage. To examine the effects of bosentan (50mg/kg and 100mg/kg) in this study, the rats were given the drug for 3months. The rats were divided into four groups: the sham group (n=10), the diabetic control group (n=10), the group of diabetic rats given bosentan 50mg/kg (n=10) and the group of diabetic rats given bosentan 100mg/kg (n=10). Diabetes was induced in the rats by STZ (60mg/kg i.p.). On day 91, all rats were killed. Brain tissues of the rats were measured by molecular, biochemical and histopathological methods. Antioxidant levels in the therapy groups were observed as quite near to the values in the healthy group. In this study, while the brain eNOS levels in the diabetic groups decreased, the ET1 and iNOS levels were found to be increased. However, in the diabetes group, hippocampus and cerebellum, pericellular oedema and a number of neuronal cytoretraction were increased in neuropiles, whereas these results were decreased in the therapy group. Based on all of these results, ET1 will not be ignored in diabetes-induced cerebral complications.en_US
dc.identifier.citationDemir, R., Cadirci, E., Akpinar, E., Cayir, Y., Atmaca, H. T., Un, H., Kunak, C. S., Yayla, M., Bayraktutan, Z., & Demir, I. (2015). Does bosentan protect diabetic brain alterations in rats? The role of endothelin-1 in the diabetic brain. Basic & clinical pharmacology & toxicology, 116(3), 236–243.en_US
dc.identifier.doi10.1111/bcpt.12318
dc.identifier.endpage243en_US
dc.identifier.issn1742-7835
dc.identifier.issn1742-7843
dc.identifier.issue3en_US
dc.identifier.pmid25200216
dc.identifier.scopus2-s2.0-84922714148
dc.identifier.scopusqualityQ2
dc.identifier.startpage236en_US
dc.identifier.urihttps://doi.org/10.1111/bcpt.12318
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6218
dc.identifier.volume116en_US
dc.identifier.wosWOS:000350099600008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleDoes Bosentan Protect Diabetic Brain Alterations in Rats? The Role of Endothelin-1 in the Diabetic Brainen_US
dc.typeArticle

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