Hepato-preventive and anti-apoptotic role of boric acid against liver injury induced by cyclophosphamide

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dc.contributor.authorCengiz, Mustafa
dc.contributor.authorYildiz, Songul Cetik
dc.contributor.authorDemir, Cemil
dc.contributor.authorSahin, Ilknur Kulcanay
dc.contributor.authorTeksoy, Ozgun
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2020-06-25T18:34:05Z
dc.date.available2020-06-25T18:34:05Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionYILDIZ, Songul CETIK/0000-0002-7855-5343; CENGIZ, Mustafa/0000-0002-6925-8371
dc.description.abstractThis study aims to examine cyclophosphamide (CP) exsposure associated toxicity on rat livers and the likely defensive effects of boric acid (BA). The rats used in this study were divided into four groups: control group, CP group, BA group, and BA + CP group. The present study was carried out using routine histological H&E stain, immunohistochemical stain caspase-3 as apoptotic marker, serum biochemical analysis for liver function markers (alanine transaminase (ALT), aspartate transaminase (AST) and alkalen phosphatase (ALP)), oxidative stress markers (total oxidant status (TOS), oxidative stress index (OSI) and total antioxidant capacity marker (TAC)). In the CP group, the levels of ALT, AST, ALP, TOS, OSI and caspase-3 increased whereas TAC levels decreased compared with the control group. In the BA + CP group, the levels of ALT, AST, ALP, TOS, OSI and caspase-3 decreased whereas TAC levels increased compared with the CP group. The histopathological evaluation of light microscope images and immunohistochemical caspase-3 activity in the BA + CP group were found to be decrease compared with those in the CP group. In conclusion, BA was successful in defending the liver against apoptosis and histopathological changes that are attributable to CP.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jtemb.2019.01.013
dc.identifier.endpage7en_US
dc.identifier.issn0946-672X
dc.identifier.pmid30910191
dc.identifier.scopus2-s2.0-85060547956
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2019.01.013
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7786
dc.identifier.volume53en_US
dc.identifier.wosWOS:000497982700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofJournal Of Trace Elements In Medicine And Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectBoric aciden_US
dc.subjectLiver injuryen_US
dc.subjectApoptosisen_US
dc.subjectOxidative stressen_US
dc.titleHepato-preventive and anti-apoptotic role of boric acid against liver injury induced by cyclophosphamideen_US
dc.typeArticle

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