Sacroiliitis in Children With Familial Mediterranean Fever

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dc.contributor.authorAydin, Fatma
dc.contributor.authorOzcakar, Z. Birsin
dc.contributor.authorCakar, Nilgun
dc.contributor.authorCelikel, Elif
dc.contributor.authorUncu, Nermin
dc.contributor.authorAcar, Banu Celikel
dc.contributor.authorYalcinkaya, Fatos
dc.date.accessioned2020-06-25T18:34:18Z
dc.date.available2020-06-25T18:34:18Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionCakar, Nilgun/0000-0002-1853-0101; Ozcakar, Zeynep/0000-0002-6376-9189
dc.description.abstractBackground/Objective Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterized by recurrent, self-limited attacks of fever with serositis. Various diseases were reported to be associated with FMF. The aim of this study was to investigate the frequency and characteristics of sacroiliitis in children with FMF. Methods Files of FMF patients who had been seen in 2 reference hospitals in Ankara were retrospectively evaluated. Patients with FMF and concomitant sacroiliitis were included to the study. All patients had magnetic resonance imaging evidence of sacroiliitis. Results Among 650 FMF patients, 17 (11 females, 6 males; mean age, 13.32 +/- 4.24 years) (2.6%) of them were found to have sacroiliitis. Familial Mediterranean fever diagnosis was done prior to sacroiliitis diagnosis in 11 patients (65%) and concurrently or afterward in 6 patients (35%). Ten patients had isolated sacroiliitis, and 7 had associated diseases (5 enthesitis-related arthritis, 1 psoriatic arthritis, and 1 ulcerative colitis). Arthritis (59%), arthralgia (77%), leg pain (71%), heel pain (41%), and enthesitis (29%) were common complaints. Sacroiliac tenderness was detected in 77%, and M694V mutation in almost 90% of the patients. All patients received colchicine therapy. Additionally, 14 of them were treated with nonsteroidal anti-inflammatory drugs, 10 were on sulfasalazine treatment, and 7 of them were on biological agents. Conclusions Sacroiliitis can be seen in patients with FMF during childhood, and M694V mutation seems to be a susceptibility factor for its development. Inflammatory low-back pain and leg and heel pain could suggest sacroiliitis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/RHU.0000000000000770
dc.identifier.endpage73en_US
dc.identifier.issn1076-1608
dc.identifier.issn1536-7355
dc.identifier.issue2en_US
dc.identifier.pmid29596210
dc.identifier.scopus2-s2.0-85062057960
dc.identifier.scopusqualityQ3
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.1097/RHU.0000000000000770
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7856
dc.identifier.volume25en_US
dc.identifier.wosWOS:000459940100003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJcr-Journal Of Clinical Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildrenen_US
dc.subjectfamilial Mediterranean feveren_US
dc.subjectM694V mutationen_US
dc.subjectsacroiliitisen_US
dc.titleSacroiliitis in Children With Familial Mediterranean Feveren_US
dc.typeArticle

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