Efficacy of topotecan treatment on an experimental model of transient evoked otoacoustic emissions

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dc.contributor.authorBayar, N.
dc.contributor.authorBoke, B.
dc.contributor.authorApan, A.
dc.contributor.authorKoc, M.C.
dc.date.accessioned2020-06-25T17:34:47Z
dc.date.available2020-06-25T17:34:47Z
dc.date.issued2001
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: The aim of this study was to investigate the effects of topotecan (Hycamtin(R)), a topoisomerase I inhibiting anticancer agent, on Transient Evoked Otoacoustic Emissions (TEOAEs) of the rabbits. We planned to investigate whether this test might provide a method for monitoring early ototoxic influence of drug administration to the cochlea. Methods: The study was conveyed in two groups each consisting of five rabbits with a total of ten ears. Rabbits in group I received i.v. topotecan (0.5 mg/kg once daily) for 3 days. Rabbits in group II received i.v. topotecan (0.25 mg/kg once daily) for 3 days. Cochlear function was serially monitored using transient evoked otoacoustic emissions before administration (BA) and on the 4th and 15th days after administration of topotecan. TEOAEs were analysed in terms of mean stimulus, stability and emission amplitude at 1.0-4.0 kHz. Results: For group I and II, intergroup and intragroup, differences were not statistically significant in the mean stimulus, stability and emission amplitudes at 1.0-4.0 kHz. Conclusions: We evaluated the potential role of TEOAEs in early identification of cochlear dysfunction induced by, topotecan. It was concluded that topotecan did not have ototoxic effects on the cochlea in the early period of administration. TEOAEs may be useful: to monitor the cochlear function and to detect the late stage of ototoxicity especially in the presence of potentially toxic factors for the prevention of permanent damage. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/S0165-5876(01)00578-X
dc.identifier.endpage142en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue2en_US
dc.identifier.pmid11589980
dc.identifier.scopus2-s2.0-0035501725
dc.identifier.scopusqualityQ2
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.1016/S0165-5876(01)00578-X
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2889
dc.identifier.volume61en_US
dc.identifier.wosWOS:000171586800006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttopotecanen_US
dc.subjectTEOAEsen_US
dc.subjectrabbitsen_US
dc.titleEfficacy of topotecan treatment on an experimental model of transient evoked otoacoustic emissionsen_US
dc.typeArticle

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