Effect of cerium oxide on erythrocyte deformability in rat lower extremity ischemia reperfusion injury

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dc.contributor.authorTatar, T.
dc.contributor.authorPolat, Y.
dc.contributor.authorComu, F. M.
dc.contributor.authorKartal, H.
dc.contributor.authorArslan, M.
dc.contributor.authorKucuk, A.
dc.date.accessioned2020-06-25T18:29:58Z
dc.date.available2020-06-25T18:29:58Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063; KARTAL, HAKAN/0000-0003-4539-0228
dc.description.abstractBACKGROUND: Cerium oxide is the oxide form of cerium, which has protective effects in ischemia reperfusion (I/R) injury. The purpose of our study was to look into the effects of this rare-earth metal on erythrocyte deformability in rat lower extremity I/R injury model. MATERIALS AND METHODS: We used 24 Wistar albino rats as subjects in our study. They were divided into 4 groups; randomized control group (group C; n = 6), cerium oxide group 0.5 mg.kg(-1), intraperitoneal (group CO; n = 6), I/R group (group I/R; n = 6) and I/R group with cerium oxide 0.5 mg.kg(-1) intraperitoneally (group I/R-CO; n = 6). Erythrocyte packs were prepared from heparinized blood samples and deformability measurements were performed. RESULTS: We obtained similar results from the control and I/R-CO groups (p = 0.158). The results in I/R group were evidently higher than those of the control, CO, and IR-CO groups (p < 0.0001, p < 0.0001, p = 0.001, respectively). CONCLUSION: We detected unfavorable effects of I/R on erythrocyte deformability, which may impair blood flow and hence tissue perfusion in infrarenal rat aorta. We also found that cerium oxide had beneficial effects by reversing undesirable effects of I/R. Further studies with larger volume are required to support our promising results (Fig. 1, Ref. 24). Text in PDF www.elis.sk.en_US
dc.identifier.citationTatar T, Polat Y, Comu FM, Kartal H, Arslan M, Kucuk A. Effect of cerium oxide on erythrocyte deformability in rat lower extremity ischemia reperfusion injury. Bratisl Lek Listy. 2018;119(7):441-443.en_US
dc.identifier.doi10.4149/BLL_2018_080
dc.identifier.endpage443en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue7en_US
dc.identifier.pmid30160134
dc.identifier.scopus2-s2.0-85050094721
dc.identifier.scopusqualityQ2
dc.identifier.startpage441en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2018_080
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7518
dc.identifier.volume119en_US
dc.identifier.wosWOS:000440978000008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectischemia reperfusionen_US
dc.subjectcerium oxideen_US
dc.subjectraten_US
dc.titleEffect of cerium oxide on erythrocyte deformability in rat lower extremity ischemia reperfusion injuryen_US
dc.typeArticle

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