An investigation of human beta-defensins and cathelicidin expression in patients with pterygium
dc.contributor.author | Karadag, Remzi | |
dc.contributor.author | Bayram, Nurettin | |
dc.contributor.author | Oguztuzun, Serpil | |
dc.contributor.author | Bayramlar, Huseyin | |
dc.contributor.author | Bozer, Busra | |
dc.contributor.author | Simsek, Gulcin | |
dc.contributor.author | Rapuano, Christopher J. | |
dc.date.accessioned | 2020-06-25T18:22:47Z | |
dc.date.available | 2020-06-25T18:22:47Z | |
dc.date.issued | 2017 | |
dc.department | Kırıkkale Üniversitesi | |
dc.description | Bozer, Busra/0000-0002-7280-4417 | |
dc.description.abstract | Purpose: To investigate human beta-defensins (HBDs) and cathelicidin LL-37 (LL-37) expressions in patients with pterygium. Methods: In this retrospective consecutive case series, 26 pterygium specimens and 15 normal conjunctival specimens of 15 control subjects were in-vestigated. Expressions of HBD-1, HBD-2, HBD-3, and LL-37 were assessed using immunohistochemical staining. A brown color in the cytoplasm and/or nuclei of epithelial cells indicated positive staining for HBDs and LL-37. For each antibody, the intensity of the reaction (negative [-], weak [1+], moderate [2+], or strong [3+]) was determined to describe the immunoreactions. Results: The median age was 52 years in both groups. There were no significant differences in age and sex between the groups (p=0.583, p=0.355, respectively). Of the 26 pterygium specimens, 15 (57.7%) (14 weak, 1 moderate staining) showed HBD-2 expression, which was not observed in any of the control specimens. One (3.8%) pterygium and one (6.7%) control specimen demonstrated weak staining for HBD-3. HBD-2 expression was significantly higher in the pterygium specimens than in the controls (p=0.002). None of the tissue specimens had positive staining for HBD-1 or LL-37 in either group (both; p=1.00). Conclusions: HBD-2 expression was higher in pterygium specimens than in the controls. HBD-2 expression that might be stimulated by inflammatory cytokines may be related to inflammation and fibrovascular proliferation and may play a role in pterygium pathogenesis. | en_US |
dc.identifier.citation | Karadag, R., Bayram, N., Oguztuzun, S., Bayramlar, H., Bozer, B., Simsek, G., & Rapuano, C. J. (2017). An investigation of human beta-defensins and cathelicidin expression in patients with pterygium. Arquivos brasileiros de oftalmologia, 80(5), 277–280. | en_US |
dc.identifier.doi | 10.5935/0004-2749.20170068 | |
dc.identifier.endpage | 280 | en_US |
dc.identifier.issn | 0004-2749 | |
dc.identifier.issn | 1678-2925 | |
dc.identifier.issue | 5 | en_US |
dc.identifier.pmid | 29160535 | |
dc.identifier.scopus | 2-s2.0-85033552727 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.startpage | 277 | en_US |
dc.identifier.uri | https://doi.org/10.5935/0004-2749.20170068 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/6904 | |
dc.identifier.volume | 80 | en_US |
dc.identifier.wos | WOS:000415347000002 | |
dc.identifier.wosquality | Q4 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | |
dc.publisher | Consel Brasil Oftalmologia | en_US |
dc.relation.ispartof | Arquivos Brasileiros De Oftalmologia | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cathelicidins | en_US |
dc.subject | Beta-defensins | en_US |
dc.subject | Immunohistochemical | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Pterygium/pathology | en_US |
dc.title | An investigation of human beta-defensins and cathelicidin expression in patients with pterygium | en_US |
dc.type | Article |
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