An investigation of human beta-defensins and cathelicidin expression in patients with pterygium

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dc.contributor.authorKaradag, Remzi
dc.contributor.authorBayram, Nurettin
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorBayramlar, Huseyin
dc.contributor.authorBozer, Busra
dc.contributor.authorSimsek, Gulcin
dc.contributor.authorRapuano, Christopher J.
dc.date.accessioned2020-06-25T18:22:47Z
dc.date.available2020-06-25T18:22:47Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionBozer, Busra/0000-0002-7280-4417
dc.description.abstractPurpose: To investigate human beta-defensins (HBDs) and cathelicidin LL-37 (LL-37) expressions in patients with pterygium. Methods: In this retrospective consecutive case series, 26 pterygium specimens and 15 normal conjunctival specimens of 15 control subjects were in-vestigated. Expressions of HBD-1, HBD-2, HBD-3, and LL-37 were assessed using immunohistochemical staining. A brown color in the cytoplasm and/or nuclei of epithelial cells indicated positive staining for HBDs and LL-37. For each antibody, the intensity of the reaction (negative [-], weak [1+], moderate [2+], or strong [3+]) was determined to describe the immunoreactions. Results: The median age was 52 years in both groups. There were no significant differences in age and sex between the groups (p=0.583, p=0.355, respectively). Of the 26 pterygium specimens, 15 (57.7%) (14 weak, 1 moderate staining) showed HBD-2 expression, which was not observed in any of the control specimens. One (3.8%) pterygium and one (6.7%) control specimen demonstrated weak staining for HBD-3. HBD-2 expression was significantly higher in the pterygium specimens than in the controls (p=0.002). None of the tissue specimens had positive staining for HBD-1 or LL-37 in either group (both; p=1.00). Conclusions: HBD-2 expression was higher in pterygium specimens than in the controls. HBD-2 expression that might be stimulated by inflammatory cytokines may be related to inflammation and fibrovascular proliferation and may play a role in pterygium pathogenesis.en_US
dc.identifier.citationKaradag, R., Bayram, N., Oguztuzun, S., Bayramlar, H., Bozer, B., Simsek, G., & Rapuano, C. J. (2017). An investigation of human beta-defensins and cathelicidin expression in patients with pterygium. Arquivos brasileiros de oftalmologia, 80(5), 277–280.en_US
dc.identifier.doi10.5935/0004-2749.20170068
dc.identifier.endpage280en_US
dc.identifier.issn0004-2749
dc.identifier.issn1678-2925
dc.identifier.issue5en_US
dc.identifier.pmid29160535
dc.identifier.scopus2-s2.0-85033552727
dc.identifier.scopusqualityQ3
dc.identifier.startpage277en_US
dc.identifier.urihttps://doi.org/10.5935/0004-2749.20170068
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6904
dc.identifier.volume80en_US
dc.identifier.wosWOS:000415347000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherConsel Brasil Oftalmologiaen_US
dc.relation.ispartofArquivos Brasileiros De Oftalmologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCathelicidinsen_US
dc.subjectBeta-defensinsen_US
dc.subjectImmunohistochemicalen_US
dc.subjectInflammationen_US
dc.subjectPterygium/pathologyen_US
dc.titleAn investigation of human beta-defensins and cathelicidin expression in patients with pterygiumen_US
dc.typeArticle

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