Healing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10

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dc.contributor.authorPehlivanli, Faruk
dc.contributor.authorAydin, Oktay
dc.contributor.authorKaraca, Gokhan
dc.contributor.authorAydin, Gulcin
dc.contributor.authorDevrim, Tuba
dc.contributor.authorBulut, Huri
dc.contributor.authorDaphan, Cagatay Erden
dc.date.accessioned2020-06-25T18:29:33Z
dc.date.available2020-06-25T18:29:33Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionAydin, Oktay/0000-0001-5728-0128; Bulut, Huri/0000-0003-2706-9625; Aydin, Gulcin/0000-0001-9672-7666
dc.description.abstractBackground: In this study, the effectiveness of dexpanthenol and coenzyme Q10 (CoQ10) on the healing of ischemic colon anastomosis was investigated. Methods: Forty eight maleWistar Albino rats were divided into four equal groups (Sham-S, Sham-I, DXP, Q10). Following full layer colon resection, single layer colon anastomosis, without creating ischemia, was performed on the Sham-S group. The same experimental model was performed on remaining groups after ischemia was created. Intraperitoneal dexpanthenol and CoQ10 was administered to the DXP and Q10 groups once a day for three days. Ten days later, all colon anastomoses were investigated histopathologically and biochemically, as well as their burst pressure values, in all sacrificed rats. Results: The highest burst pressure value was observed in the Sham-S group, decreasing from high to low in the DXP, Q10, and Sham-I groups, respectively (p = 0.008). Furthermore, tissue hydroxyproline (p = 0.001) level values were significantly different among the groups. Additionally, histopathological analysis revealed a significant difference among groups regarding reepithelization (p = 0.027) and polymorphonuclear leukocyte density (p = 0.022). Conclusions: This preliminary study has shown that ischemia-reperfusion injury may impair the healing of colon anastomosis and it has been concluded that dexpanthenol and CoQ10 may have positive effects on the healing of ischemic colon anastomosis in rat, although re-epithelization may be adversely affected using CoQ10.en_US
dc.description.sponsorshipKirikkale University Scientific Research Project Coordination UnitKirikkale University [2015-020]en_US
dc.description.sponsorshipThis study was financially supported by Kirikkale University Scientific Research Project Coordination Unit (Project Number: 2015-020).en_US
dc.identifier.citationPehlivanlı F, Aydin O, Karaca G, Aydin G, Devrim T, Bulut H, Bakar B, Daphan ÇE. Healing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10. Journal of Clinical Medicine. 2018; 7(7):161.en_US
dc.identifier.doi10.3390/jcm7070161
dc.identifier.issn2077-0383
dc.identifier.issue7en_US
dc.identifier.pmid29941836
dc.identifier.scopus2-s2.0-85103864585
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm7070161
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7369
dc.identifier.volume7en_US
dc.identifier.wosWOS:000440213800005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpien_US
dc.relation.ispartofJournal Of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdexpanthenolen_US
dc.subjectCoenzyme coenzyme Q10en_US
dc.subjectanastomosisen_US
dc.subjectcolonen_US
dc.subjectischemiaen_US
dc.titleHealing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10en_US
dc.typeArticle

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