Increased Oxidative DNA Damage in Lean Normoglycemic Offspring of Type 2 Diabetic Patients

Basit Öğe Kaydı
dc.contributor.authorZengi, A.
dc.contributor.authorErcan, G.
dc.contributor.authorCaglayan, O.
dc.contributor.authorTamsel, S.
dc.contributor.authorKaradeniz, M.
dc.contributor.authorSimsir, I.
dc.contributor.authorOzgen, G.
dc.date.accessioned2020-06-25T17:51:40Z
dc.date.available2020-06-25T17:51:40Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.descriptionkaradeniz, muammer/0000-0002-3345-5437
dc.description.abstractObjective: Several studies have shown increased oxidative stress in patients with pre-diabetes and newly diagnosed Type 2 diabetes mellitus (T2DM). It has been proposed that oxidative stress initiates insulin resistance in genetically predisposed individuals. The aim of this study was to evaluate the markers of oxidative stress in the off spring of patients with T2DM. Material and Methods: We examined 60 lean normoglycemic off spring of Type 2 diabetics, and 52 age, sex and body mass index matched subjects without family history of T2DM as controls. Anthropometric, biochemical and carotid intima media thickness (IMT) measurements and oral glucose tolerance test (OGTT) were performed. Erythrocyte superoxide dismutase and glutathione peroxidase activities, serum nitric oxide, plasma total sulfhydryl (tSH) groups, plasma total antioxidant status, plasma malondialdehyde and serum 8-hydroxydeoxy-guanosine (8-OHdG) levels were compared between 2 groups. Results: 2 groups were similar for the measurements of anthropometric, blood pressure, lipids, fasting glucose, HOMA-IR and carotid IMT. Glucose levels during OGTT were significantly higher in the off spring of Type 2 diabetics than controls (p = 0.035). The off spring of Type 2 diabetics showed a significant increase in serum 8-OHdG level (p = 0.005) and plasma tSH groups (p = 0.032) when compared to the controls. Significant differences were not obtained in other oxidative stress marker levels between 2 groups. Conclusion: Main finding of our study was the presence of increased oxidative DNA damage in lean normoglycemic off spring of Type 2 diabetic patients. There is a need for further clinical studies in order to explain whether oxidative stress is present in genetically predisposed subjects and induces the insulin resistance.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1055/s-0031-1275289
dc.identifier.endpage471en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue8en_US
dc.identifier.pmid21472659
dc.identifier.scopus2-s2.0-80052651807
dc.identifier.scopusqualityQ2
dc.identifier.startpage467en_US
dc.identifier.urihttps://doi.org/10.1055/s-0031-1275289
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4947
dc.identifier.volume119en_US
dc.identifier.wosWOS:000295612100004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbhen_US
dc.relation.ispartofExperimental And Clinical Endocrinology & Diabetes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectoxidative DNA damageen_US
dc.subjectoffspringen_US
dc.subjectType 2 diabetesen_US
dc.titleIncreased Oxidative DNA Damage in Lean Normoglycemic Offspring of Type 2 Diabetic Patientsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Increased Oxidative DNA Damage in Lean Normoglycemic Offspring of Type 2 Diabetic Patients.pdf
Boyut:
416.62 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu