The Administration of Steroids and its Impact on Caspase-3 Expression in Pediatric Adenoid Hypertrophy

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dc.authoridDirican, Onur/0000-0003-0511-6611
dc.contributor.authorApaydin, Emre
dc.contributor.authorYasar, Buse
dc.contributor.authorSimsek, Gulcin
dc.contributor.authorKaygin, Pinar
dc.contributor.authorSarialtin, Sezen Yilmaz
dc.contributor.authorDirican, Onur
dc.contributor.authorCetin, Hazal Eylem
dc.date.accessioned2025-01-21T16:44:51Z
dc.date.available2025-01-21T16:44:51Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectiveAdenoid hypertrophy is a prevalent pediatric condition, often necessitating surgical intervention. Intranasal steroid administration shows promise as a conservative treatment, particularly by inducing apoptosis in adenoidal cells, leading to a reduction in adenoid size and inflammation. This study aims to characterize the expression profile of caspase-3 as an apoptotic inducer protein in inflammatory and epithelial adenoid tissues and explore its association with steroid administration. MethodsWe performed immunohistochemical staining for caspase-3 proteins in adenoid tissues obtained from 51 pediatric patients aged between 2.5 and 12 years (mean age: 6.09 +/- 2.1 years) who underwent adenoid surgery. A retrospective analysis of clinical data was conducted, categorizing participants into steroid treatment receivers (n = 25) and non-receivers (n = 26). Subsequently, the lymphoid inflammatory tissue and epithelial tissue from the adenoid were compared in terms of caspase-3 protein expression, and associated clinical variables were assessed. ResultsImmunohistochemical analysis revealed significant caspase-3 expression in inflammatory tissues. The expression levels were scored, and no significant correlation was observed between inflammation and epithelium based on caspase-3 expression (correlation coefficient = 0.143; p > 0.05). Furthermore, demographic and clinical characteristics did not show a statistically significant difference in caspase-3 expression levels. ConclusionCaspase-3 expression was significant in inflammatory adenoid tissue, but it showed no association with nasal steroid administration.
dc.description.sponsorshipUniversity of Kimath;rimath;kkale, scientific [2022/052]
dc.description.sponsorshipThis study has been supported by University of K & imath;r & imath;kkale, scientific research projects coordination unit grant No 2022/052.
dc.identifier.doi10.1007/s12070-024-04900-8
dc.identifier.issn2231-3796
dc.identifier.issn0973-7707
dc.identifier.pmid39376326
dc.identifier.scopus2-s2.0-85198947894
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s12070-024-04900-8
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25534
dc.identifier.wosWOS:001272643400005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer India
dc.relation.ispartofIndian Journal of Otolaryngology and Head & Neck Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAdenoid Hypertrophy; Pediatric; Caspase-3; Immunohistochemical; Inflammation; Epithelium
dc.titleThe Administration of Steroids and its Impact on Caspase-3 Expression in Pediatric Adenoid Hypertrophy
dc.typeArticle

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