Immunohistochemical Expressions of the Antimicrobial Peptides (hBD-3 and hCAP-18/LL-37) in Colon, Stomach and Lung Adenocarcinomas

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dc.contributor.authorKilic, Murat
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorSimsek, Gulcin
dc.contributor.authorCakir, Ebru
dc.date.accessioned2020-06-25T18:15:58Z
dc.date.available2020-06-25T18:15:58Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionKilic, Murat/0000-0002-1377-2021
dc.description.abstractThis study investigated the immunohistochemical staining characteristics of human beta defensin-3 (hBD-3) and human cationic antimicrobial peptide-18/cathelicidin (hCAP-18/LL-37) in colon, stomach and lung adenocarcinomas and normal tissues (periphery to tumor tissues) from 22, 24 and 24 patients, respectively. Expressions of hBD-3 and hCAP-18/LL-37 were assessed by immunohistochemistry for colon, stomach and lung adenocarcinomas of 70 patients from Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital and Kecioren Training and Research Hospital. both located in Ankara, Turkey. The differences between the expressions of hBD-3 and hCAP-18/LL-37 in normal and carcinoma tissues were analyzed by Mann-Whitney U Test. When the normal and tumor tissues of these cases were compared according to their staining intensity of positive staining, the hBD-3 and hCAP-18/LL-37 expressions in colon, stomach and lung adenocarcinomas cells were significantly higher than those in normal cells (p<0.05). Immunostaining of HBD-3 and hCAP-18/LL-37 was found to be a marker of malignancy in colon, stomach and lung adenocarcinomas. The expressions of hBD-3 and hCAP-18/LL-37 were, for the first time, shown to be significantly altered in colon, stomach and lung adenocarcinomas as compared to controls. In conclusion, the present findings suggest that beside the antimicrobial activity of Antimicrobial Peptides (AMPs), hBD-3 and hCAP-18/LL-37 can also play a role in the pathogenesis of colon, stomach and lung adenocarcinomas.en_US
dc.identifier.citationKılıç M., Oğuztüzün S., Şimşek G., Çakır E. (2015). Immunohistochemical Expressions of the Antimicrobial Peptides (hBD-3 and hCAP-18/LL-37) in Colon, Stomach and Lung Adenocarcinomas. Uluslararası Hematoloji-Onkoloji Dergisi, 25(3), 149 - 157.en_US
dc.identifier.doi10.4999/uhod.15625
dc.identifier.endpage157en_US
dc.identifier.issn1306-133X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84943525527
dc.identifier.scopusqualityQ4
dc.identifier.startpage149en_US
dc.identifier.trdizinid187292
dc.identifier.urihttps://doi.org/10.4999/uhod.15625
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6367
dc.identifier.volume25en_US
dc.identifier.wosWOS:000362622100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenocarcinomaen_US
dc.subjecthBD-3en_US
dc.subjecthCAP-18/LL-37en_US
dc.subjectImmunohistochemistryen_US
dc.titleImmunohistochemical Expressions of the Antimicrobial Peptides (hBD-3 and hCAP-18/LL-37) in Colon, Stomach and Lung Adenocarcinomasen_US
dc.typeArticle

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