Calpain 10 gene single-nucleotide 44 polymorphism may have an influence on clinical and metabolic features in patients with polycystic ovary syndrome

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dc.contributor.authorYilmaz, M.
dc.contributor.authorYurtcu, E.
dc.contributor.authorDemirci, H.
dc.contributor.authorErgün, M. A.
dc.contributor.authorErsoy, R.
dc.contributor.authorKarakoç, A.
dc.contributor.authorArslan, M.
dc.date.accessioned2020-06-25T17:48:52Z
dc.date.available2020-06-25T17:48:52Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionergun, mehmet ali/0000-0001-9696-0433
dc.description.abstractAim: This study was designed in order to examine the relationship between Calpain 10 [single-nucleotide polymorphism (SNP) 19,43,44,63] gene polymorphisms and clinical and hormonal characteristics in women with polycystic ovary syndrome (PCOS). Materials and methods: One hundred and seven patients with PCOS and 114 healthy subjects were included in this study. Serum levels of sex steroids were measured for each individual. Insulin resistance (IR) was evaluated by the homeostasis model assessment (HOMA) and quantitative insulin-sensitivity check index (QUICKI) methods. Insulin and glucose responses to the oral glucose tolerance test (OGTT) were analyzed by calculating the areas under the curve for insulin (AUCI) and glucose by the trapezoidal methods. We used PCR and restriction fragment length polymorphism technique to examine Calpain 10 SNP 19, 43, 44, and 63 polymorphisms. Results: Allele distribution of Calpain 10 SNP 44 gene polymorphism was observed as significantly different between the groups. Calpain 10 SNP 44 TC genotype was found to be increased in PCOS subjects (69.15%) compared to the control subjects (50%). However, when compared to control subjects, patients with PCOS had similar Calpain 10 SNP 19, Calpain 10 SNP 43, and SNP 63 gene polymorphisms. When compared with normal Calpain 10 gene SNP 44 allele in PCOS subjects, subjects with PCOS having Calpain 10 gene SNP 44 allele polymorphism had higher free testosterone, androstenedione, DHEA-S, and fasting insulin levels. Also, PCOS women with Calpain 10 gene SNP 44 allele polymorphism had high Ferriman-Gallwey (F-G) score, acne, prevalence of menstrual disturbances, waist-hip ratio, HOMA-IR, AUCI levels and low QUICKI levels. Conclusion: The findings show that Calpain 10 gene SNP 44 allele polymorphism may have a role in PCOS pathogenesis. However, larger-scale studies are needed in this field.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage17en_US
dc.identifier.issn1720-8386
dc.identifier.issue1en_US
dc.identifier.pmid19337008
dc.identifier.scopus2-s2.0-64549110731
dc.identifier.scopusqualityQ1
dc.identifier.startpage13en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4582
dc.identifier.volume32en_US
dc.identifier.wosWOS:000264938300003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAndrogenen_US
dc.subjectCalpain 10 geneen_US
dc.subjecthirsutismusen_US
dc.subjectinsulin resistanceen_US
dc.subjectPCOSen_US
dc.subjectPCR RFLPen_US
dc.titleCalpain 10 gene single-nucleotide 44 polymorphism may have an influence on clinical and metabolic features in patients with polycystic ovary syndromeen_US
dc.typeArticle

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