Cardioprotective Effect of Selenium Against Cyclophosphamide-Induced Cardiotoxicity in Rats

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dc.contributor.authorGunes, Sibel
dc.contributor.authorSahinturk, Varol
dc.contributor.authorKarasati, Pinar
dc.contributor.authorSahin, Ilknur Kulcanay
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2020-06-25T18:23:03Z
dc.date.available2020-06-25T18:23:03Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionGunes, Sibel/0000-0003-0846-1170; Sahinturk, Varol/0000-0003-2317-3644
dc.description.abstractThe objective of this study is to evaluate the possible protective effects of selenium (Se) against cyclophosphamide (CP)-induced acute cardiotoxicity in rats. A total of 42 male Spraque-Dawley rats were divided into six groups (n = 7). Rats in the first group were served as control. Rats in the second group received CP (150 mg/kg) at the sixth day of experiment. Animals in the third and fourth groups were treated with only 0.5 and 1 mg/kg Se respectively for six consecutive days. Rats in the fifth and sixth groups received respective Se doses (0.5 or 1 mg/kg) for 6 days and then a single dose of CP administered on the sixth day. On day 7, the animals were sacrificed; blood samples were collected to measure malondialdehyde (MDA), glutathione (GSH), lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), and ischemia-modified albumin (IMA) levels. Heart tissues were processed routinely and tissue sections were stained with H + E for light microscopic examination. In the CP-treated rats MDA, LDH, CK-MB, and IMA serum levels increased, while GSH levels decreased. Microscopic evaluation showed that tissue damage was conspicuously lower in CP plus Se groups. Moreover, 1 mg/kg Se was more protective than 0.5 mg/kg Se as indicated by histopathological and biochemical values. In conclusion, Se is suggested to be a potential candidate to ameliorate CP-induced cardiotoxicity which may be related to its antioxidant activity.en_US
dc.description.sponsorshipEskisehir Osmangazi University Scientific Research Project, Turkey [P.N 2014-254]en_US
dc.description.sponsorshipThis study was financially supported by grants (P.N 2014-254) from the Eskisehir Osmangazi University Scientific Research Project, Turkey.en_US
dc.identifier.citationclosedAccess
dc.identifier.doi10.1007/s12011-016-0858-1
dc.identifier.endpage114en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid27709497
dc.identifier.scopus2-s2.0-84990818362
dc.identifier.scopusqualityQ1
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-016-0858-1
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6992
dc.identifier.volume177en_US
dc.identifier.wosWOS:000398712400014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectOxidative stressen_US
dc.subjectCardiotoxicityen_US
dc.subjectSeleniumen_US
dc.subjectIschemia modified albuminen_US
dc.titleCardioprotective Effect of Selenium Against Cyclophosphamide-Induced Cardiotoxicity in Ratsen_US
dc.typeArticle

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