Genotoxicity testing of four food preservatives and their combinations in the Drosophila wing spot test

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dc.contributor.authorSarıkaya, Rabia
dc.contributor.authorÇakır, Şükran
dc.date.accessioned2020-06-25T17:40:19Z
dc.date.available2020-06-25T17:40:19Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, four food preservatives (sodium nitrate, sodium nitrite, potassium nitrate and potassium nitrite) and there five combinations at a concentration of 25 mM have been evaluated for genotoxicity in the somatic mutation and recombination test (SMART) of Drosophila melanogaster. Three-day-old larvae trans-heterozygous including two linked recessive wing hair mutations (multiple wing hairs and flare) were fed at different concentrations of the test compounds (25, 50, 75 and 100 mM) in standard Drosophila Instant Medium. Wings of the emerging adult flies were scored for the presence of spots of mutant cells, which can result from either somatic mutation or mitotic recombination. Also lethal doses of food preservatives used were determined in the experiments. A positive correlation was observed between total mutations and the number of wings having mutation. In addition, the observed mutations in each wing were classified according to the size and type of the mutation. For the evaluation of genotoxic effects, the frequencies of spots per wing in the treated series were compared to the control group, which is distilled water. Chemicals used were ranked as sodium nitrite, potassium nitrite, sodium nitrate and potassium nitrate according to their genotoxic and toxic effects. Moreover, the genotoxic and toxic effects produced by the combined treatments were considerably increased, especially when the four chemicals were mixed. The present study shows that correct administration of food preservatives/additives may have a significant effect on human health. (c) 2005 Elsevier B.V. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.etap.2005.05.002
dc.identifier.endpage430en_US
dc.identifier.issn1382-6689
dc.identifier.issn1872-7077
dc.identifier.issue3en_US
dc.identifier.pmid21783622
dc.identifier.scopus2-s2.0-24944508127
dc.identifier.scopusqualityQ1
dc.identifier.startpage424en_US
dc.identifier.urihttps://doi.org/10.1016/j.etap.2005.05.002
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3395
dc.identifier.volume20en_US
dc.identifier.wosWOS:000232649300007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEnvironmental Toxicology And Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectsomatic mutation and recombination testen_US
dc.subjectfood preservativesen_US
dc.subjectgenetic toxicologyen_US
dc.titleGenotoxicity testing of four food preservatives and their combinations in the Drosophila wing spot testen_US
dc.typeArticle

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