The impact of bone marrow-derived mesenchymal stem cells on experimental testicular torsion in rats

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dc.authoridDemir, Sabri/0000-0003-4720-912X
dc.authoridErtürk, Ahmet/0000-0003-0286-362X
dc.contributor.authorErtürk, Ahmet
dc.contributor.authorDemir, Sabri
dc.contributor.authorGünal, Yasemin Dere
dc.contributor.authorZengin, Mehmet
dc.contributor.authorÇınar, Miyase
dc.contributor.authorYıldız, Dinçer
dc.contributor.authorKarahan, Siyami
dc.date.accessioned2025-01-21T16:34:39Z
dc.date.available2025-01-21T16:34:39Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: The aim of this study was to investigate the healing effects of bone marrow-derived mesenchymal stem cells (BM-MSCs) on experimental testicular torsion in rats. Materials and methods: Three groups consisting of 10 Wistar albino rats were created. In Group I, the left testicle was explored and relocated in the scrotum without any attempt to modify it. In Group II, the left testicle underwent torsion for three h and then was detorsed and relocated. In Group III, in addition to torsion and detorsion, BM-MSCs were administered intratesticularly. The rats were sacrificed on the seventh day, and the healing status of the testicles was investigated with histopathological and biochemical analyses. BM-MSC involvement was investigated by immunofluorescence microscopy. Statistical analysis was performed using SPSS 15.0. A p-value < 0.05 was considered statistically significant for all variables. Results: Immunofluorescence microscopy showed that BM-MSCs were located around the Leydig cells in Group III. Under light microscopy, the mean Johnsen Score of Group III was significantly higher than that of Group II (p = 0.035). The interleukin-10 (IL-10) level was significantly higher in Group III compared to Group II (p = 0.003). While the malondialdehyde (MDA) values in Group I (the control group) were lower than in the other groups (p = 0.037), the superoxide dismutase (SOD) values were similar (p = 0.158). Although there was no statistically significant difference between Group II and Group III in terms of MDA, it was lower in Group III. Although the tissue SOD levels were higher in Group III than in Group II, the difference was not statistically significant. Conclusion: This study has demonstrated that BM-MSCs significantly corrected the Johnsen Score and increased anti-inflammatory cytokine levels after testicular torsion. BM-MSCs can be used in testicular torsion as supportive therapy to minimize tissue damage.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale University (KU-BAP) [:2017-058]
dc.description.sponsorshipThis study was supported by a grant (No:2017-058) of the Scientific Research Projects Coordination Unit of Kirikkale University (KU-BAP). The authors have no conflicts of interest to declare. This study was presented at the 37th Annual Congress of Turkish Pediatric Surgical Association & STEPS 2019 held on 15-19 October 2019.
dc.identifier.doi10.55730/1300-0144.5339
dc.identifier.endpage+
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2
dc.identifier.pmid38812980
dc.identifier.scopus2-s2.0-85138647624
dc.identifier.scopusqualityQ1
dc.identifier.startpage505
dc.identifier.trdizinid518847
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5339
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay518847
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23998
dc.identifier.volume52
dc.identifier.wosWOS:000804954400027
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTesticular torsion; children; bone marrow-derived mesenchymal stem cells
dc.titleThe impact of bone marrow-derived mesenchymal stem cells on experimental testicular torsion in rats
dc.typeArticle

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