Effects of Low Dose Methotrexate in Cerebral Ischemia Reperfusion Injury in Rat

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dc.contributor.authorBakar, Bulent
dc.contributor.authorKose, Emine Arzu
dc.contributor.authorSari, Elif
dc.contributor.authorSarkarati, Bahram
dc.contributor.authorAtasoy, Pinar
dc.date.accessioned2020-06-25T18:15:46Z
dc.date.available2020-06-25T18:15:46Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: During cerebral ischemia reperfusion injury, oxidative stress leads to excitotoxicity, blood brain barrier dysfunction and inflammation. This study was designed to evaluate possible protective effects of low dose methotrexate on cerebral transient ischemia reperfusion injury in rat. Methods: Except CONTROL group, temporary aneurysm clips were performed to both common carotid arteries of rats for duration of 30 minutes. Four hours later, except CONTROL and SHAM groups, methotrexate (1.25 mg/kg/day) was administered intraperitoneally. Seventy two hours later, animals of CONTROL, MTX-A and SHAM-A group; and ten days later animals of MTX-C and SHAM-C group were sacrificed and hippocampal pyknotic neuronal cell count results and tissue lipid peroxidation (LPO) values were analyzed statistically. Results: Pyknotic cell count values of CONTROL group were lower than SHAM-A, SHAM-C, MTX-A and MTX-C group values. Cell count values of SHAM-A and MTX-A group were higher than SHAM-C and MTX-C values, respectively. LPO values of CONTROL group were lower than SHAM-A and MTX-A values, but not different from MTX-C and SHAM-C values. LPO values of MTX-A group higher than MTX-C group values. Conclusion: Cell count values and LPO values demonstrated that low dose methotrexate could not prevent neuronal cells from destructive effects of transient ischemia reperfusion injury in rat.en_US
dc.identifier.citationBakar B., Köse E. A., Sarı E., Sarkaratı B., Atasoy P. (2015). Effects of Low Dose Methotrexate in Cerebral Ischemia Reperfusion Injury in Rat. Journal of Neurological Sciences (Turkish), 32(3), 507 - 518.en_US
dc.identifier.endpage518en_US
dc.identifier.issn1302-1664
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84944199103
dc.identifier.scopusqualityN/A
dc.identifier.startpage507en_US
dc.identifier.trdizinid183516
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6278
dc.identifier.volume32en_US
dc.identifier.wosWOS:000365428100005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal Of Neurological Sciences-Turkish
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLow dose methotrexateen_US
dc.subjectischemia reperfusion injuryen_US
dc.subjectpyknotic neuronen_US
dc.subjectlipid peroxidationen_US
dc.titleEffects of Low Dose Methotrexate in Cerebral Ischemia Reperfusion Injury in Raten_US
dc.typeArticle

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