Interleukin-6 and hepcidin expression changes in cardiac tissue of long-term trained and untrained rats after exhaustive exercise

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dc.contributor.authorSarikaya, Badegul
dc.contributor.authorDursun, Ali Dogan
dc.contributor.authorTaylan Deveden, Elcin Yagmur
dc.contributor.authorPinar, Lamia
dc.date.accessioned2020-06-25T18:23:24Z
dc.date.available2020-06-25T18:23:24Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionDURSUN, ALI DOGAN/0000-0001-9056-0025
dc.description.abstractBackground/aim: Exercise benefits the cardiovascular system, but strenuous exercise can cause cardiac damage and induce cytokine production, particularly that of interleukin-6 (IL-6). Hepcidin, which is primarily regulated by IL-6, increases after exercise. Hepcidin is a possible protective factor against the adverse effects of strenuous exercise such as oxidative stress. The aim of the study is to reveal that training increases hepcidin and attenuates increased levels of IL-6 in the hearts of exhaustively exercised rats by comparing the IL-6 and hepcidin mRNA expression levels in trained and untrained groups. Materials and methods: Thirty male Wistar albino rats were assigned to the following groups: sedentary controls (Con); untrained animals that acutely completed exhaustive exercise and were sacrificed immediately after exhaustion (UT-i) or 1 day after exhaustion (UT-1); and long-term trained animals that completed exhaustive exercise and were sacrificed immediately after exhaustion (T-i) or 1 day after exhaustion (T-1). mRNA levels were examined by reverse transcription PCR. Results: IL-6 levels significantly increased in the UT-i, T-i, and T-1 groups compared to the Con group (P = 0.000, P = 0.024, P = 0.001), with maximal IL-6 expression found in the UT-i group. Hepcidin levels significantly increased in the T-1 group (P = 0.000) compared to the control. Conclusion: Increased IL-6 levels in rats show that exhaustive exercise can cause cardiac inflammation. However, long-term training attenuated the severity of the inflammation. The possible protective effect of increased hepcidin in the trained groups can be explained by the antiinflammatory effects of IL-6 and long-term training.en_US
dc.description.sponsorshipGazi University Research FundsGazi University [01/2013-09]en_US
dc.description.sponsorshipThis study was supported by Gazi University Research Funds (Grant No. 01/2013-09). Any experiments described in this paper were undertaken with the approval of the Ethics Committee of Gazi University (No. GUIET-06.096, date: 25.09.2012).en_US
dc.identifier.citationSarıkaya B., Dursun A. D., Deveden E. Y. T., Pınar L. (2017). Interleukin-6 and hepcidin expression changes in cardiac tissue of long-term trained and untrained rats after exhaustive exercise. Turkish Journal of Medical Sciences, 47(6), 1940 - 1946en_US
dc.identifier.doi10.3906/sag-1703-73
dc.identifier.endpage1946en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid29306260
dc.identifier.scopus2-s2.0-85038446835
dc.identifier.scopusqualityQ1
dc.identifier.startpage1940en_US
dc.identifier.trdizinid254950
dc.identifier.urihttps://doi.org/10.3906/sag-1703-73
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7093
dc.identifier.volume47en_US
dc.identifier.wosWOS:000418884300040
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepcidinen_US
dc.subjectinterleukin-6en_US
dc.subjecthearten_US
dc.subjectexhaustive exerciseen_US
dc.titleInterleukin-6 and hepcidin expression changes in cardiac tissue of long-term trained and untrained rats after exhaustive exerciseen_US
dc.typeArticle

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