Vascular Endothelial (VEGF) and Epithelial Growth Factor (EGF) as Well as Platelet-Activating Factor (PAF) and Receptors are Expressed in the Early Pregnant Canine Uterus

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dc.contributor.authorSchaefer-Somi, S.
dc.contributor.authorSabitzer, S.
dc.contributor.authorKlein, D.
dc.contributor.authorReinbacher, E.
dc.contributor.authorKanca, H.
dc.contributor.authorBeceriklisoy, H. B.
dc.contributor.authorAslan, S.
dc.date.accessioned2020-06-25T18:07:29Z
dc.date.available2020-06-25T18:07:29Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionKucukaslan, Ibrahim/0000-0002-3458-4409;
dc.description.abstractContents The aim of this study was to investigate the course of expression of platelet-activating factor (PAF), PAF-receptor (PAF-R), epidermal growth factor (EGF), EGF-R, vascular endothelial growth factor (VEGF), VEGF-R1 and VEGF-R2 in uterine tissue during canine pregnancy. For this purpose, 20 bitches were ovariohysterectomized at days 1012 (n = 10), 1825 (n = 5) and 2845 (n = 5) days after mating, respectively. The pre-implantation group was proven pregnant by embryo flushing of the uterus after the operation, the others by sonography. Five embryo negative, that is, non-pregnant, bitches in diestrus (day 1012) served as controls. Tissue samples from the uterus (placentation sites and horn width, respectively) were excised and snap-frozen in liquid nitrogen after embedding in Tissue Tec (R). Extraction of mRNA for RT-PCR was performed with Tri-Reagent. In the embryos, mRNA from all factors except VEGF was detected. In the course of pregnancy, significantly higher expression of PAF and PAFR as well as VEGF and VEGFR2 during the pre-implantation stage than in all other stages and a strong upregulation of EGF during implantation were characteristic. The course of EGF was in diametrical opposition to the course of the receptor. These results point towards an increased demand for VEGF, EGF and PAF during the earliest stages of canine pregnancy.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1439-0531.2012.02019.x
dc.identifier.endpage26en_US
dc.identifier.issn0936-6768
dc.identifier.issue1en_US
dc.identifier.pmid22458960
dc.identifier.scopus2-s2.0-84871702420
dc.identifier.scopusqualityQ2
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org/10.1111/j.1439-0531.2012.02019.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5589
dc.identifier.volume48en_US
dc.identifier.wosWOS:000313875800008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofReproduction In Domestic Animals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleVascular Endothelial (VEGF) and Epithelial Growth Factor (EGF) as Well as Platelet-Activating Factor (PAF) and Receptors are Expressed in the Early Pregnant Canine Uterusen_US
dc.typeArticle

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