Effects of B2O3 (boron trioxide) on colon cancer cells: our first-step experience and in vitro results

Basit Öğe Kaydı
dc.contributor.authorAlbuzi, Ozgur
dc.contributor.authorDulger, Dilek
dc.contributor.authorTunali, Beste Cagdas
dc.contributor.authorAydin, Feray
dc.contributor.authorYalcin, Selim
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2020-06-25T18:34:32Z
dc.date.available2020-06-25T18:34:32Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionALBUZ, OZGUR/0000-0002-8534-1781
dc.description.abstractBoron oxide (B2O3) is derived from dehydration of boric acid and is a colorless, semitransparent, crystalline compound that is moderately soluble in water. On the other hand, boron oxide is chemically hygroscopic. This gives the molecule the ability to soak up water and adhere to tissues. Boron oxide can be used locally after tumor debulking in inoperable tumors and especially when the twnor-free margin distance cannot be provided. For all these reasons we aimed to evaluate the in vitro test results of B2O3, in terms of cytotoxicity, genotoxicity, apoptosis, and necrotic effects on L929 fibroblast cells and DLD-1 colorectal adenocarcinoma cells. Our studies demonstrated that boron oxide compounds appear to be highly cytotoxic for both cell lines according to WST cell viability assay (44.22% and 18.36% on DLD-1 and L929, respectively). Although no genotoxic effects were observed, boron oxide compounds showed antiproliferative effects for both cell lines. The prepared boron oxide compounds may hold the potential to be applied locally to the remaining tissue after surgery and further research and evaluation will be needed to determine its effectivenesss.en_US
dc.identifier.citationAlbuz Ö., Dülger D., Tunalı B. Ç., Aydın F., Yalçın S., Türk M. (2019). Effects of B2O3 (boron trioxide) on colon cancer cells: our first-step experience and in vitro results. Turkish Journal of Biology, 43(3), 209 - 223.en_US
dc.identifier.doi10.3906/biy-1901-34
dc.identifier.endpage223en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue3en_US
dc.identifier.pmid31320819
dc.identifier.scopus2-s2.0-85071079631
dc.identifier.scopusqualityQ1
dc.identifier.startpage209en_US
dc.identifier.trdizinid336039
dc.identifier.urihttps://doi.org/10.3906/biy-1901-34
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7947
dc.identifier.volume43en_US
dc.identifier.wosWOS:000471268100006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBoron oxideen_US
dc.subjectL929 fibroblast cellsen_US
dc.subjectDLD-1 colorectal adenocarcinoma cellsen_US
dc.subjectin vitroen_US
dc.titleEffects of B2O3 (boron trioxide) on colon cancer cells: our first-step experience and in vitro resultsen_US
dc.typeArticle

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