The effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis

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dc.contributor.authorNas, Kemal
dc.contributor.authorKılıç, Erkan
dc.contributor.authorTekeoğlu, İbrahim
dc.contributor.authorKeskin, Yaşar
dc.contributor.authorÇevik, Remzi
dc.contributor.authorSargın, Betül
dc.contributor.authorAcer Kasman, Sevtap
dc.date.accessioned2021-01-14T18:10:24Z
dc.date.available2021-01-14T18:10:24Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionYurdakul, Ozan Volkan/0000-0003-4567-8133; Keskin, Yasar/0000-0003-4457-5917; TEKEOGLU, IBRAHIM/0000-0003-3395-7178; alkan, hakan/0000-0001-8461-9131; CEVIK, REMZI/0000-0002-4124-1586
dc.description.abstractObjectives In this study, we aimed to evaluate the effect of gender on clinical findings, disease activity, functional status and quality of life in patients with axial involvement in Turkey. Methods Patients with PsA who met the CASPAR classification criteria were enrolled consequently in this cohort. Turkish League Against Rheumatism (TLAR)-Network was formed with the participation of 25 centres. The demographic variables, fatigue, diagnostic delay, the beginning of peripheral arthritis, enthesitis, dactylitis and spine involvement, inflammatory low back pain, BASFI, HAQ, HAQ-s, visual analogue scale-pain (VAS-pain), anxiety, depression and disease activity parameters (ESR, DAS28, BASDAI) were recorded. Axial involvement was assessed according to clinical and radiological data according to modified New York (MNYC) or Assessment of SpondyloArthritis international Society (ASAS) criteria. Results A total of 1018 patients with PsA were included in this study. Of the 373 patients with axial involvement, 150 were male (40.2%) and 223 (59.8%) were female. Spondylitis was detected in 14,7% of men and 21,9% of women in all patients. Pain score (VAS) (p < .002), fatigue (p < .001), ESR (p < .001), DAS28 (p < .001), BASDAI score (p < .001), PsAQoL (p < .001), HAQ score (p < ,01), HAQ-S score (p < .001), anxiety (p < .001), depression (p < .024), FACIT (p < .001) and FiRST (p < .001) scores were statistically significantly worse in women than males with axial PsA. However, quality of life was better (p < .001) and PASI score (p < .005) were statistically worse in male patients than in female patients with axial involvement. Conclusion This study has shown that the burden of disease in axial PsA has significant difference between genders. Disease activity, physical disability, functional limitation, depression and anxiety scores were higher in female patients, while quality of life were better and PASI score were higher in male patients. Therefore, we suggest that new strategies should be developed for more effective treatment of axial PsA in female patients.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/14397595.2020.1812870
dc.identifier.issn1439-7595
dc.identifier.issn1439-7609
dc.identifier.pmid32820672
dc.identifier.scopus2-s2.0-85091045265
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/14397595.2020.1812870
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12570
dc.identifier.wosWOS:000570006900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofMODERN RHEUMATOLOGY
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPsoriatic arthritisen_US
dc.subjectaxial involvementen_US
dc.subjectgenderen_US
dc.subjectquality of lifeen_US
dc.subjectrisk factorsen_US
dc.titleThe effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritisen_US
dc.typeReview Article

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