Evaluation of tularaemia courses: a multicentre study from Turkey

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dc.contributor.authorErdem, H.
dc.contributor.authorOzturk-Engin, D.
dc.contributor.authorYesilyurt, M.
dc.contributor.authorKarabay, O.
dc.contributor.authorElaldi, N.
dc.contributor.authorCelebi, G.
dc.contributor.authorAgalar, C.
dc.date.accessioned2020-06-25T18:07:57Z
dc.date.available2020-06-25T18:07:57Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionGencer, Serap/0000-0002-3217-6305; balkan, ilker inanc/0000-0002-8977-5931; Yasar, Kadriye Kart/0000-0003-2963-4894; Karakas, Ahmet/0000-0002-0553-8454; Elaldi, Nazif/0000-0002-9515-770X; KARABAY, OGUZ/0000-0003-1514-1685; Asan, Ali/0000-0002-8856-7356; Karabay, Oguz/0000-0003-0502-432X
dc.description.abstractIn this multicentre study, which is the largest case series ever reported, we aimed to describe the features of tularaemia to provide detailed information. We retrospectively included 1034 patients from 41 medical centres. Before the definite diagnosis of tularaemia, tonsillitis (n=653, 63%) and/or pharyngitis (n=146, 14%) were the most frequent preliminary diagnoses. The most frequent clinical presentations were oropharyngeal (n=832, 85.3%), glandular (n=136, 13.1%) and oculoglandular (n=105, 10.1%) forms. In 987 patients (95.5%), the lymph nodes were reported to be enlarged, most frequently at the cervical chain jugular (n=599, 58%), submandibular (n=401, 39%), and periauricular (n=55, 5%). Ultrasound imaging showed hyperechoic and hypoechoic patterns (59% and 25%, respectively). Granulomatous inflammation was the most frequent histological finding (56%). The patients were previously given antibiotics for 1176 episodes, mostly with -lactam/-lactamase inhibitors (n=793, 76%). Antituberculosis medications were provided in seven (2%) cases. The patients were given rational antibiotics for tularaemia after the start of symptoms, with a mean of 26.8 +/- 37.5days. Treatment failure was considered to have occurred in 495 patients (48%). The most frequent reasons for failure were the production of suppuration in the lymph nodes after the start of treatment (n=426, 86.1%), the formation of new lymphadenomegalies under treatment (n=146, 29.5%), and persisting complaints despite 2weeks of treatment (n=77, 15.6%). Fine-needle aspiration was performed in 521 patients (50%) as the most frequent drainage method. In conclusion, tularaemia is a long-lasting but curable disease in this part of the world. However, the treatment strategy still needs optimization.en_US
dc.identifier.citationErdem, H., Ozturk-Engin, D., Yesilyurt, M., Karabay, O., Elaldi, N., Celebi, G., Korkmaz, N., Guven, T., Sumer, S., Tulek, N., Ural, O., Yilmaz, G., Erdinc, S., Nayman-Alpat, S., Sehmen, E., Kader, C., Sari, N., Engin, A., Cicek-Senturk, G., Ertem-Tuncer, G., … Agalar, C. (2014). Evaluation of tularaemia courses: a multicentre study from Turkey. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(12), O1042–O1051.en_US
dc.identifier.doi10.1111/1469-0691.12741
dc.identifier.endpageO1051en_US
dc.identifier.issn1198-743X
dc.identifier.issn1469-0691
dc.identifier.issue12en_US
dc.identifier.pmid24975504
dc.identifier.scopus2-s2.0-84920364101
dc.identifier.scopusqualityQ1
dc.identifier.startpageO1042en_US
dc.identifier.urihttps://doi.org/10.1111/1469-0691.12741
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5699
dc.identifier.volume20en_US
dc.identifier.wosWOS:000346723700011
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofClinical Microbiology And Infection
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClinical courseen_US
dc.subjecthistopathologyen_US
dc.subjectsurgeryen_US
dc.subjecttherapyen_US
dc.subjecttularaemiaen_US
dc.subjectultrasounden_US
dc.titleEvaluation of tularaemia courses: a multicentre study from Turkeyen_US
dc.typeArticle

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