The role of CD14 gene promoter polymorphism in tuberculosis susceptibility

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dc.contributor.authorAyaslioglu, Ergin
dc.contributor.authorKalpaklioglu, Fusun
dc.contributor.authorKavut, Ayse Baccioglu
dc.contributor.authorErturk, Arzu
dc.contributor.authorCapan, Nermin
dc.contributor.authorBirben, Esra
dc.date.accessioned2020-06-25T18:07:12Z
dc.date.available2020-06-25T18:07:12Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: CD14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in the innate immunity to intracellular infections. Recent research findings have revealed an association between the CD14 gene promoter polymorphism and several major infectious diseases. Objective: The aim of the present study was to investigate the association between the CD14-159C/T polymorphism and tuberculosis in a Turkish population. Methods: For this purpose, 88 consecutive patients with tuberculosis (63 pulmonary, 25 extra-pulmonary) and 116 control subjects were enrolled into a prospective study. We determined CD14-159 genotypes by polymerase chain reaction - restriction fragment length polymorphism analysis and also measured serum concentrations of soluble CD14 (sCD14) by using a quantitative sandwich enzyme immunoassay technique. Results: There was no significant difference in terms of genotype distribution between patients with tuberculosis (CC 18.2%, CT 48.9%, TT 33.0%) and controls (CC 12.9%, CT 50.9%, TT 36.2%) or between patients with pulmonary and extrapulmonary tuberculosis. Serum levels of sCD14 were significantly increased in patients with active tuberculosis compared to those with inactive tuberculosis and healthy controls (p < 0.001). However, levels of sCD14 were not associated with any genotypes of CD14-159. Conclusion: The genotyping findings of the present study do not support a role for the CD14-159C/T polymorphism in the development of tuberculosis, at least in the geographical region of central Anatolia. Significantly elevated serum sCD14 levels in patients with active disease reflect the importance of the mononuclear phagocytic system activation in tuberculosis. Copyright (C) 2012, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.description.sponsorshipKirikkale UniversityKirikkale University [2008/7]en_US
dc.description.sponsorshipThis work was supported by the Kirikkale University Research Fund (Grant no: 2008/7).en_US
dc.identifier.citationAyaslioglu, E., Kalpaklioglu, F., Kavut, A. B., Erturk, A., Capan, N., & Birben, E. (2013). The role of CD14 gene promoter polymorphism in tuberculosis susceptibility. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 46(3), 158–163.en_US
dc.identifier.doi10.1016/j.jmii.2012.05.008
dc.identifier.endpage163en_US
dc.identifier.issn1684-1182
dc.identifier.issn1995-9133
dc.identifier.issue3en_US
dc.identifier.pmid23036271
dc.identifier.scopus2-s2.0-84879275034
dc.identifier.scopusqualityQ1
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org/10.1016/j.jmii.2012.05.008
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5512
dc.identifier.volume46en_US
dc.identifier.wosWOS:000322609600003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofJournal Of Microbiology Immunology And Infection
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCD14en_US
dc.subjectpolymorphismen_US
dc.subjectsoluble CD14en_US
dc.subjecttuberculosisen_US
dc.titleThe role of CD14 gene promoter polymorphism in tuberculosis susceptibilityen_US
dc.typeArticle

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