Predictors of clinical outcome following extended thymectomy in myasthenia gravis

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dc.contributor.authorÖzdemir, N.
dc.contributor.authorKara, M.
dc.contributor.authorDikmen, E.
dc.contributor.authorNadir, A.
dc.contributor.authorAkal, M.
dc.contributor.authorYucemen, N.
dc.contributor.authorYavuzer, S.
dc.date.accessioned2020-06-25T17:35:36Z
dc.date.available2020-06-25T17:35:36Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Thymectomy remains as the optimal treatment of choice in patients with myasthenia gravis (MG), however, the selection criteria for surgery remains controversial. Methods: We examined the data charts of patients with MG underwent extended thymectomy. We investigated the possible correlations between the clinicopathologic features and clinical outcomes, and analyzed the data to clarify the effect of prognostic factors on clinical outcome. Results: A total of 61 patients with a mean age of 35.8 +/- 12.2 years (range, 13-66 years) were analyzed. The overall improvement/remission and clinical worsening rates were 81.9 and 18.1%, respectively. Ossermann stage (P = 0.011) and presence of mediastinal ectopic thymic tissue (P = 0.007) showed a significant correlation with the clinical outcome. Multivariate analysis confirmed Ossermann stage (P = 0.0158), and presence of mediastinal ectopic thymic tissue (P = 0.0100) as independent predictors on clinical outcome. Conclusion: Ossermann stage and the presence of mediastinal ectopic thymic tissue are potential predictors on clinical outcome in patients with MG undergoing extended thymectomy. (C) 2002 Elsevier Science B.V. All rights reserved.en_US
dc.identifier.citationOzdemir, N., Kara, M., Dikmen, E., Nadir, A., Akal, M., Yücemen, N., & Yavuzer, S. (2003). Predictors of clinical outcome following extended thymectomy in myasthenia gravis. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 23(2), 233–237. https://doi.org/10.1016/s1010-7940(02)00744-3en_US
dc.identifier.doi10.1016/S1010-7940(02)00744-3
dc.identifier.endpage237en_US
dc.identifier.issn1010-7940
dc.identifier.issue2en_US
dc.identifier.pmid12559348
dc.identifier.scopus2-s2.0-12244284581
dc.identifier.scopusqualityQ1
dc.identifier.startpage233en_US
dc.identifier.urihttps://doi.org/10.1016/S1010-7940(02)00744-3
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3161
dc.identifier.volume23en_US
dc.identifier.wosWOS:000180995200021
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Cardio-Thoracic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmyasthenia gravisen_US
dc.subjectthymectomyen_US
dc.subjectclinical outcomeen_US
dc.titlePredictors of clinical outcome following extended thymectomy in myasthenia gravisen_US
dc.typeArticle

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