Assessment of the Relationship Between Serum High Molecular Weight Adiponectin Hormone Levels and Insulin Resistance in Patients with Polycystic Ovary Syndrome

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dc.contributor.authorPekcan, Meryem Kuru
dc.contributor.authorTokmak, Aytekin
dc.contributor.authorAkkaya, Hatice
dc.contributor.authorPekcan, Gultekin
dc.contributor.authorOnur, Andac
dc.contributor.authorKisa, Ucler
dc.contributor.authorCil, Aylin Pelin
dc.date.accessioned2020-06-25T18:34:09Z
dc.date.available2020-06-25T18:34:09Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Tokmak, Aytekin/0000-0001-5739-5689
dc.description.abstractThe purpose of this study was to assess the rate of insulin resistance (IR) and the relationship between IR and high-molecular weight adiponectin (HMWA) in patients with polycystic ovary syndrome (PCOS). A cross sectional study involving 43 women with PCOS and 39 normal women was carried out over a period of nine months. Fasting glucose and insulin levels, lipid parameters and androgen levels were measured in all serum samples. HMWA was determined by enzyme-linked immunosorbent assay and IR was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR) index. The IR was more prevalent in the PCOS group than in the controls (p = 0.002). Dehydroepiandrosterone sulfate, sex hormone binding globulin, free androgen index, total testosterone, insulin, and HOMA-IR levels were significantly higher in the PCOS group as compared to the control group (all p < 0.05). Moreover, HMWA was significantly lower and negatively correlated with the clinical and biochemical hyperandrogenism in the PCOS group. HMWA and HOMA-IR were also associated with triglyceride, body mass index, and fat mass in this group. ROC curve analyses demonstrated that the AUC, indicative of the HMWA value for discriminating PCOS with IR, was 0.725, with a confidence interval of 0.615-0.835 (p = 0.001). The serum HMWA levels are lower in patients with PCOS, which suggest that HMWA might be involved in the pathogenesis of PCOS. We also conclude that HMWA might be a strong determinant of IR in PCOS patients.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1055/a-0867-0886
dc.identifier.endpage266en_US
dc.identifier.issn0018-5043
dc.identifier.issn1439-4286
dc.identifier.issue4en_US
dc.identifier.pmid31022741
dc.identifier.scopus2-s2.0-85064971741
dc.identifier.scopusqualityQ2
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.1055/a-0867-0886
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7811
dc.identifier.volume51en_US
dc.identifier.wosWOS:000466544100007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofHormone And Metabolic Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpolycystic ovarian syndromeen_US
dc.subjecthigh-molecular weight adiponectinen_US
dc.subjectinsulin resistanceen_US
dc.subjecthyperandrogenemiaen_US
dc.subjectHOMA-IRen_US
dc.titleAssessment of the Relationship Between Serum High Molecular Weight Adiponectin Hormone Levels and Insulin Resistance in Patients with Polycystic Ovary Syndromeen_US
dc.typeArticle

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