Histomorphometric evaluation of the effects of zoledronic acid on mandibular distraction osteogenesis in rabbits

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dc.contributor.authorPampu, A. Alper
dc.contributor.authorDolanmaz, Dogan
dc.contributor.authorTüz, Hakan H.
dc.contributor.authorAvunduk, M. Cihat
dc.contributor.authorKisnisci, Reha S.
dc.date.accessioned2020-06-25T17:44:42Z
dc.date.available2020-06-25T17:44:42Z
dc.date.issued2008
dc.descriptionKisnisci, Reha/0000-0003-3397-4947
dc.description.abstractPurpose: To assess the effect of systemic administration of zoledronic acid (ZA) on mineralization of newly formed bone and to determine strain-related osteoporosis on surrounding bone during lengthening of immature rabbit mandible. Materials and Methods: Eighteen New Zealand white rabbits were divided randomly into 2 groups, and bone lengthening was carried out in the left portion of the mandible through distraction osteogenesis with a rate of 0.5 mm every 12 hours for 5 days. The experimental group was administered 0.1 mg/kg ZA intravenously. The control group was given saline infusion only during operation. All animals were sacrificed at the end of the 28-day consolidation period. The mandibles of all animals were removed and regenerate was evaluated. Osteoblasts, osteoclasts, collagen fibers, and fibroblasts were marked within 0.1-mm(2) area and newly formed bone area was measured within 0.5-mm(2) area. All data were analyzed using Mann-VAiitney U test. Results: Although irregular bone destruction spots were seen in the control group, the experimental group showed regular ossification areas and significant difference between osteoblast and osteoclast numbers (P < .05). In the regenerate zone, there was considerable difference between the 2 groups in terms of osteoblast, osteoclast, and collagen amounts (P < .05). Additionally, newly formed bone areas and fibroblast count were higher in experimental group. Conclusions: The results of this study showed that ZA had positive effects on the new bone formation, which may potentially shorten the consolidation period. (c) 2008 American Association of Oral and Maxillofacial Surgeons.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.joms.2007.12.004
dc.identifier.endpage910en_US
dc.identifier.issn0278-2391
dc.identifier.issn1531-5053
dc.identifier.issue5en_US
dc.identifier.pmid18423279
dc.identifier.scopus2-s2.0-41949121748
dc.identifier.scopusqualityQ1
dc.identifier.startpage905en_US
dc.identifier.urihttps://doi.org10.1016/j.joms.2007.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4174
dc.identifier.volume66en_US
dc.identifier.wosWOS:000255540500012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Oral And Maxillofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleHistomorphometric evaluation of the effects of zoledronic acid on mandibular distraction osteogenesis in rabbitsen_US
dc.typeArticle

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