Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

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dc.authoridKul, Bengi Çınar/0000-0002-8955-0097
dc.contributor.authorKul, Bengi Çınar
dc.contributor.authorBilgen, Nuket
dc.contributor.authorBiskin, Merve
dc.contributor.authorAkkurt, Mustafa Yenal
dc.contributor.authorÇıldır, Özge Şebnem
dc.contributor.authorÖzmen, Özge
dc.contributor.authorKul, Oğuz
dc.date.accessioned2025-01-21T16:34:13Z
dc.date.available2025-01-21T16:34:13Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractMammals have physiological reprogramming adaptation ability to changing seasonal light and temperature, through their biological clocks maintained by circadian rhythm, photoperiodism and thermoperiodism. Seasonal differences do not only affect vital activities of animals like migration, reproduction, and sleeping, but also cause dramatic changes in their economically important characteristics (e.g. fur quality and fattening level). Mohair is constituted of non-medullary hairs produced by secondary hair follicles in Angora goats and the effects of seasonal differences on mohair structure and related genes are still unknown. We examined the gene expression levels of BMP-2, FGF-5, HOXC13, KAP9.2 and TGFBR2 normalized with GAPDH in skin biopsies taken from Angora goats (n=20) in two different follicle development stages; telogen (in February) and anagen (in June). HOXC13 showed overexpression in anagen phase (P<0.005) whereas expression was undetectable in telogen phase. BMP-2 (P<0.005), FGF-5 (P<0.005) and TGFBR2 (P<0.01) were significantly upregulated in anagen, while KAP9.2 expression showed no difference between two phases. This is the first study on hair follicle-related genes in the angora goat. Additionally, depending the role of HOXC13 in pathways, it suggests that its overexpression may be one of the main factors associated with the non-medullary hair structure in Angora goats.
dc.description.sponsorshipAnkara University Scientific Research Projects Coordination Unit [15B0239003]
dc.description.sponsorshipFunding Support This study was supported by the Ankara University Scientific Research Projects Coordination Unit. Project Code: 15B0239003, 2015.
dc.identifier.doi10.9775/kvfd.2023.29327
dc.identifier.endpage372
dc.identifier.issn1300-6045
dc.identifier.issn1309-2251
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85167417017
dc.identifier.scopusqualityQ3
dc.identifier.startpage365
dc.identifier.trdizinid1281900
dc.identifier.urihttps://doi.org/10.9775/kvfd.2023.29327
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1281900
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23913
dc.identifier.volume29
dc.identifier.wosWOS:001016597000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAnagen; Hair follicle development; Mohair goat; Secondary hair follicles; Telogen
dc.titleSeasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats
dc.typeArticle

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