Bispectral index-guided intraoperative sedation with dexmedetomidine and midazolam infusion in outpatient cataract surgery

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dc.contributor.authorApan, Alparslan
dc.contributor.authorDoganci, N.
dc.contributor.authorErgan, A.
dc.contributor.authorBüyükkoçak, Ünase
dc.date.accessioned2020-06-25T17:48:28Z
dc.date.available2020-06-25T17:48:28Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground. This study aimed to evaluate the role of alpha-(2) agonist in fusion, with dexmedetomidine or midazolam, on hemodynamic and respiratory parameters while titrating the sedation level with the bispectral index (BIS) during cataract surgery. Methods. Ninety consenting ASA class I-III patients who were electively undergoing cataract surgery were en rolled in the double blind study. A random infusion of 0.25 mu gxkg(-1) xhr(-1) Dexmedetomidine (Group D), 25 mu g x kg-1.hr(-1) midazolam (Group M), or saline for controls (Group Q was administered after mounting a BIS monitor and routine anesthetic care. The target BIS level was >85. An additional bolus dose in 1 mL increments of the study drug or cessation of the infusion was adjusted according to the BIS level. Changes in respiratory and vital parameters were noted and, in case of mild pain, 25 mu g fentanyl was administered as a bolus. Pain and sedation were evaluated in the early postoperative period using Visual analogue and four rating sedation scales. Results. In Group D, heart rate decreased in the later periods Of surgery (35-50 min) and in the early postoperative Period (5(th) and 15(th) min). Dose adjustments were required in six and tell patients in Groups D and M, respectively Pain scores were lower with dexmedetomidine infusion. Conclusion. Dexmedetomidine infusion mildly decreased heart rate in the later periods of surgery with better pain scores in the postoperative period. Dexmedetomidine Should be an alternative for intraoperative sedation ill Outpatient cataract Surgery.en_US
dc.identifier.citationApan, A., Doganci, N., Ergan, A., & Büyükkoçak, U. (2009). Bispectral index-guided intraoperative sedation with dexmedetomidine and midazolam infusion in outpatient cataract surgery. Minerva anestesiologica, 75(5), 239–244.en_US
dc.identifier.endpage244en_US
dc.identifier.issn0375-9393
dc.identifier.issue5en_US
dc.identifier.pmid19088698
dc.identifier.scopus2-s2.0-67650188992
dc.identifier.scopusqualityQ2
dc.identifier.startpage239en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4459
dc.identifier.volume75en_US
dc.identifier.wosWOS:000265842600002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofMinerva Anestesiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectConscious sedationen_US
dc.subjectIntraoperative perioden_US
dc.subjectDexmedetomidineen_US
dc.subjectMidazolamen_US
dc.titleBispectral index-guided intraoperative sedation with dexmedetomidine and midazolam infusion in outpatient cataract surgeryen_US
dc.typeArticle

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