Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis

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dc.authoridKARA, Erdal/0000-0001-7047-9502
dc.contributor.authorKurtdede, Efe
dc.contributor.authorKurtdede, Arif
dc.contributor.authorOcal, Naci
dc.contributor.authorKara, Erdal
dc.date.accessioned2025-01-21T16:33:22Z
dc.date.available2025-01-21T16:33:22Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, it was aimed to investigate the serum levels of ANGPTL4, FGF21, IL-1 beta, IL-6, SOD, MDA, and serum biochemical and hematological parameters in cows with subclinical ketosis. The mean serum beta-hydroxybutyric acid (BHB) level was 1.37 +/- 0.04 mmol/L in 10 dairy cows aged 3-5 years that were <21 days postpartum and diagnosed with subclinical ketosis. The mean serum BHB level was 0.40 +/- 0.08 mmol/L in 10 healthy dairy cows in the same period and in the same age range. An increase in serum AST (P<0.001) and a decrease in serum albumin levels (P<0.05) indicated altered liver functions. An increase in serum non-esterified fatty acid (P<0.001) and decreases in serum HDL, triglyceride, and total cholesterol levels (P<0.05) were interpreted as indicators of increased metabolic pathology risk due to negative energy balance. Increases in serum ANGPTL4, FGF2, IL-1 beta, IL-6, and MDA (P<0.001) and SOD levels (P<0.05) were evaluated as indicators of the development of effective metabolic, inflammatory, and oxidative stress. It was concluded that significant increases in serum ANGPTL4, FGF2, IL- 1 beta, IL-6, and MDA and SOD levels in dairy cows with subclinical ketosis were associated with negative energy balance, effective cytokine responses, and oxidative stress.
dc.description.sponsorshipAnkara University Scientific Research Grant [20B0239002]
dc.description.sponsorshipThis study was supported by Ankara University Scientific Research Grant (Grant No: 20B0239002).
dc.identifier.doi10.33988/auvfd.907076
dc.identifier.endpage42
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85145028506
dc.identifier.scopusqualityQ3
dc.identifier.startpage37
dc.identifier.trdizinid1152622
dc.identifier.urihttps://doi.org/10.33988/auvfd.907076
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1152622
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23788
dc.identifier.volume70
dc.identifier.wosWOS:001047216600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectCytokines; Dairy cows; Energy-related biochemical; Hepatokines; Subclinical ketosis
dc.titleSerum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis
dc.typeArticle

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