Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis
dc.authorid | KARA, Erdal/0000-0001-7047-9502 | |
dc.contributor.author | Kurtdede, Efe | |
dc.contributor.author | Kurtdede, Arif | |
dc.contributor.author | Ocal, Naci | |
dc.contributor.author | Kara, Erdal | |
dc.date.accessioned | 2025-01-21T16:33:22Z | |
dc.date.available | 2025-01-21T16:33:22Z | |
dc.date.issued | 2023 | |
dc.department | Kırıkkale Üniversitesi | |
dc.description.abstract | In this study, it was aimed to investigate the serum levels of ANGPTL4, FGF21, IL-1 beta, IL-6, SOD, MDA, and serum biochemical and hematological parameters in cows with subclinical ketosis. The mean serum beta-hydroxybutyric acid (BHB) level was 1.37 +/- 0.04 mmol/L in 10 dairy cows aged 3-5 years that were <21 days postpartum and diagnosed with subclinical ketosis. The mean serum BHB level was 0.40 +/- 0.08 mmol/L in 10 healthy dairy cows in the same period and in the same age range. An increase in serum AST (P<0.001) and a decrease in serum albumin levels (P<0.05) indicated altered liver functions. An increase in serum non-esterified fatty acid (P<0.001) and decreases in serum HDL, triglyceride, and total cholesterol levels (P<0.05) were interpreted as indicators of increased metabolic pathology risk due to negative energy balance. Increases in serum ANGPTL4, FGF2, IL-1 beta, IL-6, and MDA (P<0.001) and SOD levels (P<0.05) were evaluated as indicators of the development of effective metabolic, inflammatory, and oxidative stress. It was concluded that significant increases in serum ANGPTL4, FGF2, IL- 1 beta, IL-6, and MDA and SOD levels in dairy cows with subclinical ketosis were associated with negative energy balance, effective cytokine responses, and oxidative stress. | |
dc.description.sponsorship | Ankara University Scientific Research Grant [20B0239002] | |
dc.description.sponsorship | This study was supported by Ankara University Scientific Research Grant (Grant No: 20B0239002). | |
dc.identifier.doi | 10.33988/auvfd.907076 | |
dc.identifier.endpage | 42 | |
dc.identifier.issn | 1300-0861 | |
dc.identifier.issn | 1308-2817 | |
dc.identifier.issue | 1 | |
dc.identifier.scopus | 2-s2.0-85145028506 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.startpage | 37 | |
dc.identifier.trdizinid | 1152622 | |
dc.identifier.uri | https://doi.org/10.33988/auvfd.907076 | |
dc.identifier.uri | https://search.trdizin.gov.tr/tr/yayin/detay1152622 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/23788 | |
dc.identifier.volume | 70 | |
dc.identifier.wos | WOS:001047216600005 | |
dc.identifier.wosquality | Q3 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | TR-Dizin | |
dc.language.iso | en | |
dc.publisher | Ankara Univ | |
dc.relation.ispartof | Ankara Universitesi Veteriner Fakultesi Dergisi | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.snmz | KA_20241229 | |
dc.subject | Cytokines; Dairy cows; Energy-related biochemical; Hepatokines; Subclinical ketosis | |
dc.title | Serum ANGPTL4 and FGF2, energy-related blood biochemicals, cytokine responses and oxidative stress in dairy cows with subclinical ketosis | |
dc.type | Article |