Comparison of the effect of contrast medium, air, and ozone on ischemia/reperfusion injury due to experimental intussusception model

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dc.contributor.authorSenyucel, Mine Fedakar
dc.contributor.authorAyva, Ebru Sebnem
dc.contributor.authorAslan, Mustafa Kemal
dc.contributor.authorBoybeyi, Ozlem
dc.contributor.authorSoyer, Tutku
dc.contributor.authorAksoy, Nurkan
dc.contributor.authorCakmak, Ahmet Murat
dc.date.accessioned2020-06-25T18:07:50Z
dc.date.available2020-06-25T18:07:50Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Soyer, Tutku/0000-0003-1505-6042
dc.description.abstractAim: To compare effects of contrast medium, air, and ozone on ischemia/reperfusion injury due to intussusception. Materials and methods: Thirty Wistar rats were allocated into five groups (n = 6). In the control group (CG), 2 cm of colonic segment, 5 cm distal to ileocecal valve, was removed. Intussusception was performed at 5 cm distal to the ileocecal valve by pushing a proximal intestinal segment distally by stile in experimental groups. One hour later, in the sham-operated group (SG), manual reduction was performed. In the reduction groups, reduction of intussusception was performed by contrast medium (CMG, 1/1 diluted omnipaqueR, infusion rate 2 mL/min), by air (AG, Pmax = 60 mmHg), or by ozone (OG, 10 mu g/mL, 0.5 mg/kg, Pmax = 60 mmHg). One hour after reduction, 2 cm of colonic segment was removed. Colonic tissues were evaluated for histopathological grades and oxidative injury markers (malondialdehyde [MDA], nitric oxide [NO], and total sulfhydryl [T-SH] values). Results: Mucosal injury score was significantly higher in AG then in CG or SG (P < 0.05). There was no difference regarding mucosal injury between the other groups (P > 0.05). MDA levels were significantly higher and NO levels were significantly lower in CMG, OG, and AG than in CG (P < 0.05). There was no difference between OG and the other experimental groups in both MDA and NO levels (P > 0.05). Conclusion: None of the reduction methods in intussusception have superiority over others in preventing ischemia/reperfusion injury.en_US
dc.description.sponsorshipKirikkale University Scientific Research CouncilKirikkale Universityen_US
dc.description.sponsorshipThis study was presented at the 29th National Congress of Turkish Pediatric Surgeons, in 2011 in Istanbul, Turkey, and was supported by the Kirikkale University Scientific Research Council.en_US
dc.identifier.citationFedakar M. Ş., Ayva E. Ş., Aslan M. K., Türer Ö. B., Soyer T., Aksoy N., Kısa Ü., Çakmak A. M. (2013). Comparison of the effect of contrast medium, air, and ozone on ischemia/reperfusion injury due to experimental intussusception model. Turkish Journal of Medical Sciences, 43(4), 637 - 641.en_US
dc.identifier.doi10.3906/sag-1206-84
dc.identifier.endpage641en_US
dc.identifier.issn1300-0144
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84880929433
dc.identifier.scopusqualityQ1
dc.identifier.startpage637en_US
dc.identifier.trdizinid150372
dc.identifier.urihttps://doi.org/10.3906/sag-1206-84
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5672
dc.identifier.volume43en_US
dc.identifier.wosWOS:000323609800025
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntussusceptionen_US
dc.subjectozoneen_US
dc.subjectintestineen_US
dc.subjectischemia-reperfusionen_US
dc.subjectinjuryen_US
dc.subjectexperimentalen_US
dc.titleComparison of the effect of contrast medium, air, and ozone on ischemia/reperfusion injury due to experimental intussusception modelen_US
dc.typeArticle

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