Apoptosis-related proteins and steroid hormone receptors in normal, hyperplastic, and neoplastic endometrium

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dc.contributor.authorBozdoğan, Önder
dc.contributor.authorAtasoy, Pınar
dc.contributor.authorErekul, Selim
dc.contributor.authorBozdoğan, Nazan
dc.contributor.authorBayram, Merih
dc.date.accessioned2020-06-25T17:34:58Z
dc.date.available2020-06-25T17:34:58Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.descriptionSymposium of the International-Society-of-Gynecological-Pathologists -- FEB 04, 2002 -- CHICAGO, IL
dc.description.abstractThe purpose of this study was to evaluate the distribution and frequency of apoptosis-related proteins and their correlation with estrogen, progesterone, and androgen receptors in endometrial tissues. Immunohistochemical analyses of bcl-2, bax, bcl-x, and steroid receptors were performed in 22 endometrial carcinomas, 26 endometrial hyperplasias, and 19 cases of normal cyclical endometrium. Bcl-2 was expressed in 45.4% of carcinomas and 92.3% of hyperplasias. Bax immunostaining was found in 90.9% of carcinomas and 76.9% of hyperplasias. Bcl-x positivity was similar in carcinomas (68.1%) and endometrial hyperplasias (76.9%). In nor-Mal cyclical endometria, bcl-2 staining was intense and diffuse in the proliferative phase, but decreased dramatically in the early and mid-secretory phase to reappear in the late secretory phase. Bax was expressed throughout the menstrual cycle but more strongly in the secretory phase. Bcl-x displayed a similar degree of expression in proliferative and secretory endometria. Nineteen carcinomas (86.3%), 25 hyperplasias (96.1%), and 18 normal cyclical endometria (94.7%) were positive for estrogen receptor (ER). Progesterone receptor (PR) was observed in 20 carcinomas (90.9%), all hyperplasias (100%), and 18 normal cyclical endometria (94.7%). Androgen receptor (AR) positivity was seen in 7 carcinomas (31.8%), 6 hyperplasias (23.0%), and 3 normal cyclical endometria (15.7%). There was a statistically positive correlation between bcl-x and ER and a tendency toward significant correlation between bcl-x and PR and between ER and PR in carcinomas. In hyperplasias, there was a significant positive correlation between bcl-2 and PR and between bcl-2 and bax and a negative correlation between ER and bax. There was a statistically significant difference for bcl-2 (p = 0.001) and bax (p = 0.001) between the hyperplasia and carcinoma groups. There was increased expression of bax. decreased expression of bcl-2, and persistence of bcl-x protein in advanced endometrial carcinomas. Our findings show that ovarian hormones have a regulatory role on bcl-2 protein and that there is a correlation between other members of the bcl-2 family (bcl-x and bax) and steroid hormone receptors. Bax/bcl-x may be the major control mechanisms of apoptosis in advanced carcinomas; other members of the bcl-2 family may also be under hormonal control.en_US
dc.description.sponsorshipInt Soc Gynecol Pathologistsen_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/01.PGP.0000035807.01856.93
dc.identifier.endpage382en_US
dc.identifier.issn0277-1691
dc.identifier.issn1538-7151
dc.identifier.issue4en_US
dc.identifier.pmid12352186
dc.identifier.scopus2-s2.0-0036784037
dc.identifier.scopusqualityQ2
dc.identifier.startpage375en_US
dc.identifier.urihttps://doi.org/10.1097/01.PGP.0000035807.01856.93
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2973
dc.identifier.volume21en_US
dc.identifier.wosWOS:000178179500007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofInternational Journal Of Gynecological Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectendometrial canceren_US
dc.subjecthyperplasiaen_US
dc.subjectapoptosisen_US
dc.subjectBcl-2en_US
dc.subjectBaxen_US
dc.subjectBcl-xen_US
dc.subjectestrogen receptoren_US
dc.subjectprogesterone receptoren_US
dc.subjectandrogen receptoren_US
dc.titleApoptosis-related proteins and steroid hormone receptors in normal, hyperplastic, and neoplastic endometriumen_US
dc.typeArticle

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