Role of macrophage microaggregation in the diagnosis of inflammatory colitis

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dc.contributor.authorAltunoglu A.
dc.contributor.authorTuncer C.
dc.contributor.authorErten S.
dc.contributor.authorKalkanci A.
dc.contributor.authorTunc B.
dc.contributor.authorUzum N.
dc.contributor.authorGüliter S.
dc.date.accessioned2020-06-25T15:17:32Z
dc.date.available2020-06-25T15:17:32Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Recent studies have advocated that the presence of macrophage microaggregations (MMA) may be a criterion in the diagnosis of Crohn's colitis (CC). In our study we aimed to investigate the role of MMA to differenti-ate ulcerative colitis (UC) and (CC). Material and Method: We analyzed the role of MMA in 29 patients with UC, 26 patients with CC and 22 healthy subjects without diagnosis of inflammatory bowel disease. For all subjects, esophagogastroduodenoscopy was performed. Biopsies were taken from non-lesion regions of stomach and duodenum. Biopsy materials underwent immunohistochemical staining for the microscopic investigation of the presence of MMA. Also, determination of Perinuclear Anti-Neutropil Cytoplasmic Antibodies (pANCA) and Anti-Saccharomyces Cerevisiae Antibodies (ASCA) (Immunoglobulin G and A) was done with ELISA in serum samples. In patient and control groups, presence of Helicobacter pylori (H. pylori) positivity was histopathologically evaluated. Results: MMA was higher in patients with both CC and UC compared with control groups (46.2%, 41.3%, and 9.1% respec-tively). There was statistically significant difference between patient groups and the control group in terms of MMA but there was no difference between CC and UC groups (p=0.007). No statistically significant difference was ob-tained between the groups in terms of ASCA and p-ANCA. H.pylori positivity was determined in 41.3% of MMA patients with CC, in 75% of patients with UC, and in 50% of healthy subjects. There was no significant difference between the three groups (p=0.344). Discussion: MMA positivity increases in patients with both CC and UC. In patients with inflammatory colitis, H. pylori existence, pANCA and ASCA positivity was similar to healthy subjects.en_US
dc.identifier.citationAltunoğlu, A., Tunçer, C., Erten, Ş., Kalkancı, A., Tunç, B., Üzüm, N., Yakaryılmaz, F., Dursun, A., Güliter, S. (2014). Role of Macrophage Microaggregation in the Diagnosis of Inflammatory Colitis. Journal of Clinical and Analytical Medicine, 5(4), 307 - 311.en_US
dc.identifier.doi10.4328/JCAM.1302
dc.identifier.endpage311en_US
dc.identifier.issn13090720
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84900328127
dc.identifier.scopusqualityN/A
dc.identifier.startpage307en_US
dc.identifier.trdizinid184244
dc.identifier.urihttps://doi.org/10.4328/JCAM.1302
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2411
dc.identifier.volume5en_US
dc.identifier.wosWOS:000215563900014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherJournal of Clinical and Analytical Medicineen_US
dc.relation.ispartofJournal of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCrohn's diseaseen_US
dc.subjectEsophagogastroduodenoscopyen_US
dc.subjectHelicobacter pylorien_US
dc.subjectMacrophage microaggregationsen_US
dc.subjectUlcerative colitisen_US
dc.titleRole of macrophage microaggregation in the diagnosis of inflammatory colitisen_US
dc.title.alternativeMakrofaj mikroagregasyonunun i?nflamatuvar kolit tanısında rolüen_US
dc.typeArticle

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