The efficacy of palbociclib and ribociclib in the first-line treatment of metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer in male patients: a Turkish oncology group (TOG) study

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dc.authoridKayikcioglu, Erkan/0000-0002-7401-5446
dc.authoridMUTLU, EMEL/0000-0002-1008-2527
dc.authoridKeskinkilic, Merve/0000-0002-3342-3144
dc.authoridYildirim, Hasan cagri/0000-0003-3060-377X
dc.authoridDulgar, Ozgecan/0000-0002-0678-4024
dc.contributor.authorYildirim, Hasan Cagri
dc.contributor.authorKutlu, Yasin
dc.contributor.authorMutlu, Emel
dc.contributor.authorAykan, Musa Baris
dc.contributor.authorKorkmaz, Mustafa
dc.contributor.authorYalcin, Selim
dc.contributor.authorSakalar, Teoman
dc.date.accessioned2025-01-21T16:45:28Z
dc.date.available2025-01-21T16:45:28Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroductionMale breast cancer, comprising approximately 1% of all breast cancer cases, often leads to the exclusion of male patients as a criterion in clinical trials. While the efficacy of Cyclin-dependent kinases 4 and 6 (CDK 4/6) inhibitors has been established in metastatic hormone receptor-positive (HR +) and human epidermal growth factor receptor 2-negative (HER2 -) breast cancer in women, limited data exist on their effectiveness in male patients.We aimed to evaluate the efficacy and safety of palbociclib or ribociclib in male patients with breast cancer.IntroductionMale breast cancer, comprising approximately 1% of all breast cancer cases, often leads to the exclusion of male patients as a criterion in clinical trials. While the efficacy of Cyclin-dependent kinases 4 and 6 (CDK 4/6) inhibitors has been established in metastatic hormone receptor-positive (HR +) and human epidermal growth factor receptor 2-negative (HER2 -) breast cancer in women, limited data exist on their effectiveness in male patients.We aimed to evaluate the efficacy and safety of palbociclib or ribociclib in male patients with breast cancer.MethodsThis study is a multicenter, retrospective study. We included male patients with HR + and HER2-metastatic breast cancer who received palbociclib or ribociclib as first-line treatment. Our primary endpoints were progression-free survival (PFS), overall response rates (ORR), and drug-related adverse effects.ResultsA total of 46 male patients from 27 institutions were enrolled. The median age at initiation of CDK 4/6 inhibitors was 63.64 +/- 13.69 years, with a median follow-up of 21.33 (95% CI 14.92-27.74) months. The ORR were 84% for palbociclib and 76.2% for ribociclib. The mPFS for the entire cohort was 28.06 months (95% CI 18.70-37.42). No significant difference in PFS was observed between palbociclib and ribociclib (mPFS: 24.46 months (95% CI 11.51-37.42) vs 28.33 months (95% CI 14.77-41.88), respectively, p = 0.211). No new adverse events were reported.DiscussionThis study demonstrates that palbociclib and ribociclib are effective and safe options for first-line treatment in male patients with HR + /HER2 - metastatic breast cancer. However, further prospective studies are warranted to establish their efficacy in this population.
dc.identifier.doi10.1007/s10147-023-02460-5
dc.identifier.endpage265
dc.identifier.issn1341-9625
dc.identifier.issn1437-7772
dc.identifier.issue3
dc.identifier.pmid38310597
dc.identifier.scopus2-s2.0-85184191440
dc.identifier.scopusqualityQ1
dc.identifier.startpage258
dc.identifier.urihttps://doi.org/10.1007/s10147-023-02460-5
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25655
dc.identifier.volume29
dc.identifier.wosWOS:001156854500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Japan Kk
dc.relation.ispartofInternational Journal of Clinical Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectMale breast cancer; CDK4/6 inhibitors; Palbociclib; Ribociclib
dc.titleThe efficacy of palbociclib and ribociclib in the first-line treatment of metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer in male patients: a Turkish oncology group (TOG) study
dc.typeArticle

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