Asymptomatic kindred of patients with coronary events have increased peripheral T-cell activities

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dc.contributor.authorSönmez, Alper
dc.contributor.authorKısa, Üçler
dc.contributor.authorUckaya, Gökhan
dc.contributor.authorEyileten, Tayfun
dc.contributor.authorKinalp, Can
dc.contributor.authorYilmaz, M. İlker
dc.contributor.authorKocar, I. Hakkı
dc.date.accessioned2020-06-25T17:43:30Z
dc.date.available2020-06-25T17:43:30Z
dc.date.issued2006
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Sonmez, Alper/0000-0002-9309-7715; Turan, Mustafa/0000-0003-4782-8596
dc.description.abstractT cells are involved in the pathogenesis of atherosclerosis. We aimed to search for any association between the peripheral T-cell activities and atherogenic risk factors in healthy subjects. Fifty male volunteers (age 22.0 +/- 2.4 years) were enrolled. No subject had any chronic disease or was under any drug treatment. Lymphocytes were isolated from heparinized venous blood and the proliferative responses to phytohemagglutinin (PHA) were measured from the amount of radioactive thymidine uptake by the lymphocyte DNA. T-cell activity responses of patients with a family history of coronary events were compared with others. The activity responses of smokers were compared with nonsmokers. Subjects with a positive family history of coronary events had higher PHA stimulated T-cell response and delta cpm (P < 0.05 for each). Total and low-density lipoprotein cholesterol levels of the subjects with a positive family history of cardiovascular events were positively correlated with the PHA-activated T-cell responses (P = 0.022, r = 0.604 and P = 0.015, r = 0.635, respectively). There was no significant difference between the T-cell activity responses of smokers and nonsmokers. No correlation was found between the biochemical parameters and T-cell activities in these groups. Peripheral T-cell activity responses to PHA are higher in the asymptomatic relatives of patients with coronary events. This may be a clue for the familial tendency of atherosclerotic diseases. Further follow-up studies are necessary to investigate the relationship.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00380-005-0893-x
dc.identifier.endpage246en_US
dc.identifier.issn0910-8327
dc.identifier.issue4en_US
dc.identifier.pmid16865300
dc.identifier.scopus2-s2.0-33748416340
dc.identifier.scopusqualityQ3
dc.identifier.startpage242en_US
dc.identifier.urihttps://doi.org10.1007/s00380-005-0893-x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3752
dc.identifier.volume21en_US
dc.identifier.wosWOS:000239297400006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofHeart And Vessels
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectT cellen_US
dc.subjectatherosclerosisen_US
dc.subjectrisk factorsen_US
dc.subjectsmokingen_US
dc.subjectlipidsen_US
dc.titleAsymptomatic kindred of patients with coronary events have increased peripheral T-cell activitiesen_US
dc.typeArticle

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