Effects of methylprednisolone on the viability of experimental flow-through venous flaps

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dc.contributor.authorSaray, A.
dc.contributor.authorCan, B.
dc.contributor.authorSevin, K.
dc.date.accessioned2020-06-25T17:34:59Z
dc.date.available2020-06-25T17:34:59Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, the effects of a corticosteroid, methylprednisolone, on the survival of flow-through venous flaps were investigated in rabbits. Flow-through venous flaps, sized 3.0 x 4.5 cm, were raised in the rabbit-ear model. Animals were randomly distributed into three groups, and 30 flaps were raised as follows: Group 1 (n=10): control flow-through venous flaps (intramuscular saline injection 2 md/d); Group 2 (n=10): flow-through venous flaps with daily intramuscular methylprednisolone injection (30 mg/kg/d); and Group 3 (n=10): negative control composite grafts with the flow-through vein ligated at both edges of the flap. All injections were done 24 hr and 1 hr preoperatively, and for 5 days postoperatively. Observations included gross and histologic examination, and percentage of survival of the flaps on the tenth day. Venous flaps of the animals receiving daily methylprednisolone injections (Group 2) were noted to have statistically significantly improved flap survival (p<0.05), compared to the control group (Group 1). Flaps in Groups 1 and 2 demonstrated significantly higher survival rates, compared to the composite grafts (p<0.01). Histologic examination of methylprednisolone-treated animals showed normal stratified squamous epithelium, while complete necrosis was noted in the composite grafts. Untreated flow-through venous flaps demonstrated patchy epidermal sloughing, crusting, and partial necrosis. These results suggest that the survival of potentially ischemic flow-through venous flaps can be enhanced in rabbits by daily methylprednisolone treatment in the perioperative period. Increased tolerance to ischemia and modulation of venous flap microcirculation might be possible mechanisms for this salutary effect.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1055/s-2002-35089
dc.identifier.endpage621en_US
dc.identifier.issn0743-684X
dc.identifier.issue7en_US
dc.identifier.pmid12404137
dc.identifier.scopus2-s2.0-0036792883
dc.identifier.scopusqualityQ1
dc.identifier.startpage615en_US
dc.identifier.urihttps://doi.org/10.1055/s-2002-35089
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2976
dc.identifier.volume18en_US
dc.identifier.wosWOS:000178546700010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherThieme Medical Publ Incen_US
dc.relation.ispartofJournal Of Reconstructive Microsurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmethylprednisoloneen_US
dc.subjectflow-throughen_US
dc.subjectvenous flapen_US
dc.subjectflap viabilityen_US
dc.titleEffects of methylprednisolone on the viability of experimental flow-through venous flapsen_US
dc.typeArticle

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