The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients

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dc.contributor.authorSerbest, Sancar
dc.contributor.authorTiftikci, Ugur
dc.contributor.authorTosun, Haci Bayram
dc.contributor.authorKisa, Ucler
dc.date.accessioned2020-06-25T18:22:43Z
dc.date.available2020-06-25T18:22:43Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractBackground: Whether or not there is a relationship between the newly-discovered irisin hormone and bone healing is not yet known. The aim of this study was to investigate what effect irisin hormone has on the bone healing process. Material/Methods: The study included 21 adult patients with a diagnosed fracture of the lower extremity (femur or tibia). Informed consent was obtained from all the patients. A total of four venous blood samples were taken from the patients: before fracture stabilization, then postoperatively on days 1, 10, and 60. In patients with femoral neck fracture who had hip prosthesis applied, bone tissue samples were taken from the removed femur head and irisin was determined immunohistochemically in muscle biopsies taken from the same patients. Results: In analysis, it was revealed that the mean value of irisin 60 days after operation is significantly higher than the values of irisin before operation, 1 day after operation, and 15 day after operation (p<0.001, p<0.001, p<0.001, respectively). Intense staining was observed in compact bone tissue, muscle tissue, and in hypertrophic vascular endothelium within the Havers canal. Conclusions: The level of irisin hormone increased in the bone union process and affects fracture healing due to irisin receptors in human bone tissue.en_US
dc.description.sponsorshipKirikkale University Scientific Research ProjectKirikkale University [2015/001]en_US
dc.description.sponsorshipThis study was funded by Kirikkale University Scientific Research Project (2015/001)en_US
dc.identifier.citationSerbest, S., Tiftikçi, U., Tosun, H. B., & Kısa, Ü. (2017). The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients. Medical science monitor : international medical journal of experimental and clinical research, 23, 4278–4283.en_US
dc.identifier.doi10.12659/MSM.906293
dc.identifier.issn1643-3750
dc.identifier.pmid28869754
dc.identifier.scopus2-s2.0-85029577430
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.12659/MSM.906293
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6877
dc.identifier.volume23en_US
dc.identifier.wosWOS:000409267600002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone and Bonesen_US
dc.subjectBone Diseases, Endocrineen_US
dc.subjectFracture Healingen_US
dc.titleThe Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patientsen_US
dc.typeArticle

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