The effects of preanesthetic, single-dose dexmedetomidine on induction, hemodynamic, and cardiovascular parameters

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dc.contributor.authorBasar, Hülya
dc.contributor.authorAkpinar, Serpil
dc.contributor.authorDoganci, Nur
dc.contributor.authorBuyukkocak, Unase
dc.contributor.authorKaymak, Cetin
dc.contributor.authorSert, Ozgur
dc.contributor.authorApan, Alpaslan
dc.date.accessioned2020-06-25T17:44:24Z
dc.date.available2020-06-25T17:44:24Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.description.abstractStudy Objectives: To investigate the hemodynamic, cardiovascular, and recovery effects of dexmedetomidine used as a single preanesthetic dose. Design: Randomized, prospective, double-blind study. Setting: University Hospital of Kirikkale, Kirikkale, Turkey. Patients: 40 ASA physical status I and II patients, aged 20 to 60 years, who were scheduled for elective cholecystectomy. Interventions: Patients were randomly divided into two groups to receive 0.5 mu g kg(-1) dexmedetomidine (group D, n = 20) or saline solution (group C, n = 20). Anesthesia was induced with thiopental sodium and vecuronium, and anesthesia was maintained with 4% to 6% desflurane. Measurements: Mean arterial pressure (MAP), heart rate (HR), (ejection fraction (EF), end-diastolic index (EDI), cardiac index (CI), and stroke volume index (SVI) were recorded at 10-minute intervals. The times for patients to "open eyes on verbal command" and postoperative Aldrete recovery scores were also recorded. Main Results: In group C, an increase in HR and MAP occurred after endotracheal intubation. In group D, HR significantly decreased after dexmedetomidine was given. The EDI, Cl, SVI, and EF values were similar in groups D and C. The modified Aldrete recovery scores of patients in the recovery room were similar in groups C and D at the 15th minute. Conclusions: A single dose of dexmedetomidine given before induction of anesthesia decreased thiopental requirements without serious hemodynamic effects or any effect on recovery time. Crown Copyright (C) 2008 Published by Elsevier Inc. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jclinane.2008.04.007
dc.identifier.endpage436en_US
dc.identifier.issn0952-8180
dc.identifier.issue6en_US
dc.identifier.pmid18929283
dc.identifier.scopus2-s2.0-53049088191
dc.identifier.scopusqualityQ1
dc.identifier.startpage431en_US
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2008.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4094
dc.identifier.volume20en_US
dc.identifier.wosWOS:000260134200006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Clinical Anesthesia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectSingle doseen_US
dc.subjectPreanesthetic doseen_US
dc.titleThe effects of preanesthetic, single-dose dexmedetomidine on induction, hemodynamic, and cardiovascular parametersen_US
dc.typeArticle

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