The antibacterial effect of mesenchymal stem cells on graft infections: An experimental study

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dc.contributor.authorKabalci, Mehmet
dc.contributor.authorCanbeyli, Ibrahim Deniz
dc.contributor.authorEroglu, Erdinc
dc.date.accessioned2020-06-25T18:29:23Z
dc.date.available2020-06-25T18:29:23Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: In this study, we aimed to investigate the antibacterial effects of mesenchymal stem cells, compared to tigecycline, on graft infection related with methicillin-resistant Staphylococcus epidermidis in a rat model. Methods: A total of 42 male adult Wistar rats (age >6 months; weight 300 to 350 g) were divided into six groups including seven rats in each. Group 0 did not undergo any procedure; Group 1 was infected, but untreated; Group 2 was infected and treated with tigecycline without graft placement; Group 3 was infected and received mesenchymal stem cells without graft placement; Group 4 was infected and treated with tigecycline after graft placement; Group 5 was infected and treated with mesenchymal stem cells after graft placement. The pockets created were either left empty or implanted with Dacron grafts. Treatment was commenced at 48 h. Specimens were collected on Day 13. Perigraft tissues were evaluated histopathologically and bacterial colony numbers were counted. Results: No bacterial colonization was observed in Group 0, whereas there was a significant colonization in Group 1. Complete eradication was achieved in Group 2 and Group 3 (graft-free groups), and near-complete eradication was achieved in Group 4 and Group 5 (graft-implanted groups). The histopathological findings significantly differed between Group 1-Group 2 and between Group 1-Group 3 (graft-free groups). The histopathological findings were similar between Group 2-Group 3 and between Group 4-Group 5. Conclusion: Our study results suggest that mesenchymal stem cells may be a novel, contemporary alternative to antibiotherapy and may decrease the bio-burden of Staphylococcus at the infected graft areas, and mesenchymal stem cell treatment may be as effective as tigecycline.en_US
dc.identifier.citationKabalcı M., Canbeyli İ. D., Eroğlu E. (2018). The antibacterial effect of mesenchymal stem cells on graft infections: An experimental study. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 26(4), 571 - 578.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2018.16049
dc.identifier.endpage578en_US
dc.identifier.issn1301-5680
dc.identifier.issue4en_US
dc.identifier.pmid32082799
dc.identifier.scopus2-s2.0-85057862576
dc.identifier.scopusqualityQ3
dc.identifier.startpage571en_US
dc.identifier.trdizinid296357
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2018.16049
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7285
dc.identifier.volume26en_US
dc.identifier.wosWOS:000450917400008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal Of Thoracic And Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfectionen_US
dc.subjectmesenchymal stem cellen_US
dc.subjectStaphylococcus epidermidisen_US
dc.subjecttigecyclineen_US
dc.subjectwounden_US
dc.titleThe antibacterial effect of mesenchymal stem cells on graft infections: An experimental studyen_US
dc.typeArticle

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