Comparison of the tissue expressions of glutathione S transferase isoenzymes among patients with morphea and healthy controls: A preliminary study

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dc.contributor.authorUzuncakmak, Tugba Kevser
dc.contributor.authorKoska, Mahmut Can
dc.contributor.authorOzkanli, Seyma
dc.contributor.authorKocdogan, Arzu Kaya
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorKaradag, Ayse Serap
dc.contributor.authorAkdeniz, Necmettin
dc.date.accessioned2021-01-14T18:10:22Z
dc.date.available2021-01-14T18:10:22Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionWollina, Uwe/0000-0001-5933-2913
dc.description.abstractMorphea is an inflammatory connective tissue disorder, which is characterized by sclerosis in skin and subcutaneous tissues with a chronic progress. The oxidative stress in pathogenesis of sclerosing diseases was proposed in several studies with conflicting results. To explore the tissue expressions of Glutathione S transferase (GST) isoenzymes in patients with morphea and compare these expressions with healthy controls. Twenty-two morphea patients and 20 sex and age matched healthy controls were enrolled in this study. Four millimeter punch biopsies were performed from the active sclerotic plaques of morphea patients. Tissue samples of control group were obtained from nonlesional normal skin biopsy specimens. The protein expressions of GST isoenzymes were analyzed immunohistochemically. Tissue expressions of GSTP1, GSTT1, and GSTA1 isoenzymes in morphea patients were found to be significantly higher than in control tissues. There was no significant difference in GSTM1 isoenzyme expression between the two groups. The increased tissue expressions of GSTA1, GSTP1, and GSTT1 isoenzymes in morphea may represent the activated GST enzymes in response to excessive free radical formation and may also support the hypothesis of increased oxidative stress in morphea etiopathogenesis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/dth.14363
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue6en_US
dc.identifier.pmid33002252
dc.identifier.scopus2-s2.0-85092151961
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/dth.14363
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12549
dc.identifier.volume33en_US
dc.identifier.wosWOS:000575935200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWILEYen_US
dc.relation.ispartofDERMATOLOGIC THERAPY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdermatopathologyen_US
dc.subjectglutathione S transferaseen_US
dc.subjectimmunohistochemistryen_US
dc.subjectlocalized sclerodermaen_US
dc.subjectmorpheaen_US
dc.subjectoxidative stressen_US
dc.titleComparison of the tissue expressions of glutathione S transferase isoenzymes among patients with morphea and healthy controls: A preliminary studyen_US
dc.typeArticle

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