The effect of Helicobacter pylori eradication on gastroesophageal reflux disease

Basit Öğe Kaydı
dc.contributor.authorGüliter, S.
dc.contributor.authorKandilci, U.
dc.date.accessioned2020-06-25T17:40:03Z
dc.date.available2020-06-25T17:40:03Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: The effect of Helicobacter pylori (H. pylori) eradication on gastroesophageal reflux disease is controversial. We aimed to investigate the effect of H. pylori eradication in this group of patients. Materials and Methods: Thirty-four consecutive patients with H. pylori infection and reflux esophagitis (grade 1 or 2) were enrolled into the study. Twenty-four hour intra-esophageal pH recording and esophageal manometry were performed before and 3 months after eradication of H. pylori, which was achieved using lansoprazole 30 mg b.i.d., amoxycillin 1 g b.i.d., and clarithromycin 500 mg b.i.d. for 14 days. H. pylori was evaluated in biopsy specimens taken from the antrum and corpus by rapid urease test and by histopathologic examination before and 3 months after eradication. Results: Eighteen patients (11 men and 7 women, median age 42 years) completed the study. Three months after the treatment, there was no significant change in any of the 24-hour esophageal pH recording parameters and mean lower esophageal sphincter resting pressure (P > 0.05). The percentage of total time esophageal pH <4 increased in 10 patients, and decreased in 8 patients. There was a significant decrease in the scores of heartburn and regurgitation (P < 0.01). Esophagitis persisted in 16 patients and disappeared in 2 patients. Esophagitis score decreased in 6 patients, and did not change in 12 patients (P < 0.05). Conclusion: H. pylori eradication does not have any effect on gastroesophageal acid reflux in patients with reflux esophagitis 3 months after eradication, but significant improvement is achieved in some reflux associated symptoms.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage755en_US
dc.identifier.issn0192-0790
dc.identifier.issn1539-2031
dc.identifier.issue9en_US
dc.identifier.pmid15365399
dc.identifier.scopus2-s2.0-4644236292
dc.identifier.scopusqualityQ2
dc.identifier.startpage750en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3233
dc.identifier.volume38en_US
dc.identifier.wosWOS:000224045400006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Clinical Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelicobacter pylorien_US
dc.subjectgastroesophageal reflux diseaseen_US
dc.subject24 hour esophageal pH-metryen_US
dc.titleThe effect of Helicobacter pylori eradication on gastroesophageal reflux diseaseen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
The effect of Helicobacter pylori eradication on gastroesophageal reflux disease.pdf
Boyut:
88.86 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu