Effectiveness of the Biophysical Barriers to the Peridural Fibrosis in Rat Laminectomy Model

Basit Öğe Kaydı
dc.contributor.authorAkkurt, Ibrahim
dc.contributor.authorBakar, Bulent
dc.contributor.authorDincel, Gungor Cagdas
dc.contributor.authorYildiran, Fatma Azize Budak
dc.contributor.authorOgden, Mustafa
dc.contributor.authorNursoy, Egemen
dc.contributor.authorSari, Elif
dc.date.accessioned2020-06-25T18:34:04Z
dc.date.available2020-06-25T18:34:04Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionYILDIRAN, Fatma Azize BUDAK/0000-0001-7031-6834; DINCEL, Gungor Cagdas/0000-0002-6985-3197
dc.description.abstractPurpose: Peridural fibrosis which could occur after the spinal surgery could adhere neural tissue closely and may cause to neural entrapment symptoms and require surgical reintervention. Aim of the study: Present study was designed to reduce occurrence of peridural fibrosis in rat laminectomy model by using biophysical barriers called hyaluronic acid (HAS) dural barrier, activated polyethylene glycol and polyethylene imine (PEG) dural barrier, and platelet-rich plasma (PRP). Materials and methods: In this study, 2 of 26 male Wistar albino rats (325-350 g body weight), which were not included into study groups were sacrificed by removing their total blood and their blood was used for preparation of PRP, and remaining rats were randomly delivered into four groups called SHAM, HAS, PEG, and PRP groups. Then L3-4-5 laminectomy was performed to all animals and experimental agents were administered to the selected groups mentioned above. Spinal colons of all animals were removed gross total after 6-week period and investigated histopathologically. Additionally, real-time-polymerase chain reaction was used to obtain collagen type I and type III, transforming growth factor-1 beta, and tumor necrosis factor-alpha gene expressions. Results: All results demonstrated that polyethylene glycol and polyethylene imine dural barrier and PRP could decrease peridural fibrosis formation efficiently in rat. Conclusion: Present study results suggested that to reduce or block formation of peridural fibrosis, either polyethylene glycol and polyethylene imine dural barrier or PRP could be used effectively in human subjects after they will be closely investigated in future studies.en_US
dc.description.sponsorshipKirikkale University Scientific Research Project Coordination UnitKirikkale University [2014/075]en_US
dc.description.sponsorshipThis study was financially supported by Kirikkale University Scientific Research Project Coordination Unit (Project Number: 2014/075).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/08941939.2017.1423422
dc.identifier.endpage368en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue4en_US
dc.identifier.pmid29345503
dc.identifier.scopus2-s2.0-85040986029
dc.identifier.scopusqualityQ1
dc.identifier.startpage361en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2017.1423422
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7783
dc.identifier.volume32en_US
dc.identifier.wosWOS:000472088700012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectperidural fibrosisen_US
dc.subjecthyaluronic aciden_US
dc.subjectpolyethylene glycolen_US
dc.subjectplatelet-rich plasmaen_US
dc.titleEffectiveness of the Biophysical Barriers to the Peridural Fibrosis in Rat Laminectomy Modelen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Effectiveness of the Biophysical Barriers to the Peridural Fibrosis in Rat Laminectomy Model.pdf
Boyut:
818.15 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu