Effect of paracetamol pretreatment on rocuronium-induced injection pain: A randomized, double-blind, placebo-controlled comparison with lidocaine
Yükleniyor...
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Journal of Clinical and Analytical Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: To compare the effect of intravenous paracetamol on rocuronium-induced injection pain with that of lidocaine. Material and Method: One hundred and eighty patients scheduled for elective surgery under general anesthesia were recruited to this prospective, randomized, double-blinded, placebo-controlled study. A 20-gauge cannula was inserted into a vein on the dorsum of the patient's left hand and lactated Ringer's solution was infused at 100 ml/h. After 5 minutes, infusion was stopped and the left arm of the patient's was elevated for 15 seconds for gravity of venous blood. While venous occlusion was applied to the left upper arm using a pneumatic tourniquet, one of the pretreatment solutions (normal saline 5 mL, lidocaine 40 mg, paracetamol 50 mg) was injected over a period of 10 seconds. The intensity of the pain patients experienced was assessed using a 4-point verbal rating scale in Group C (normal saline 5 mL, n=60), Group L (lidocaine 40 mg, n=60) and Group P (paracetamol 50 mg, n=60). After 2 minutes, the venous occlusion was released and the patients received 0.06 mg/kg rocuronim bromide over 10 seconds and the rocuronim-induced pain was assessed. Results: The overall incidence of rocuronium-induced injection pain was significantly more in Group C than the other groups (p<0.001). The overall incidence of the rocuronium-induced injection pain was significantly less in Group L than in Group P and in Group C (p=0.009 and p<0.001, respectively). Additionally, the overall incidence of the rocuronium-induced injection was less in Group P than the Group C (p=0.002). Discussion: Intravenous pretreatment with paracetamol was effective in reducing the incidence and intensity of rocuronium-induced injection pain, but not as effective as intravenous lidocaine pretreatment.
Açıklama
Anahtar Kelimeler
Injection pain, Lidocaine, Paracetamol, Rocuronium
Kaynak
Journal of Clinical and Analytical Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
5
Sayı
6
Künye
Ateş, G., Köse, E. A., Öz, G., Apan, A. (2014). Effect of Paracetamol Pretreatment on Rocuronium-Induced Injection Pain: A Randomized, Double-Blind, Placebo-Controlled Comparison with Lidocaine. Journal of Clinical and Analytical Medicine, 5(6), 507 - 510.
