Effect of paracetamol pretreatment on rocuronium-induced injection pain: A randomized, double-blind, placebo-controlled comparison with lidocaine

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dc.contributor.authorAteş G.
dc.contributor.authorKöse E.A.
dc.contributor.authorÖz G.
dc.contributor.authorApan A.
dc.date.accessioned2020-06-25T15:17:27Z
dc.date.available2020-06-25T15:17:27Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: To compare the effect of intravenous paracetamol on rocuronium-induced injection pain with that of lidocaine. Material and Method: One hundred and eighty patients scheduled for elective surgery under general anesthesia were recruited to this prospective, randomized, double-blinded, placebo-controlled study. A 20-gauge cannula was inserted into a vein on the dorsum of the patient's left hand and lactated Ringer's solution was infused at 100 ml/h. After 5 minutes, infusion was stopped and the left arm of the patient's was elevated for 15 seconds for gravity of venous blood. While venous occlusion was applied to the left upper arm using a pneumatic tourniquet, one of the pretreatment solutions (normal saline 5 mL, lidocaine 40 mg, paracetamol 50 mg) was injected over a period of 10 seconds. The intensity of the pain patients experienced was assessed using a 4-point verbal rating scale in Group C (normal saline 5 mL, n=60), Group L (lidocaine 40 mg, n=60) and Group P (paracetamol 50 mg, n=60). After 2 minutes, the venous occlusion was released and the patients received 0.06 mg/kg rocuronim bromide over 10 seconds and the rocuronim-induced pain was assessed. Results: The overall incidence of rocuronium-induced injection pain was significantly more in Group C than the other groups (p<0.001). The overall incidence of the rocuronium-induced injection pain was significantly less in Group L than in Group P and in Group C (p=0.009 and p<0.001, respectively). Additionally, the overall incidence of the rocuronium-induced injection was less in Group P than the Group C (p=0.002). Discussion: Intravenous pretreatment with paracetamol was effective in reducing the incidence and intensity of rocuronium-induced injection pain, but not as effective as intravenous lidocaine pretreatment.en_US
dc.identifier.citationAteş, G., Köse, E. A., Öz, G., Apan, A. (2014). Effect of Paracetamol Pretreatment on Rocuronium-Induced Injection Pain: A Randomized, Double-Blind, Placebo-Controlled Comparison with Lidocaine. Journal of Clinical and Analytical Medicine, 5(6), 507 - 510.en_US
dc.identifier.doi10.4328/JCAM.1632
dc.identifier.issn13090720
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84900302470
dc.identifier.scopusqualityN/A
dc.identifier.trdizinid184134
dc.identifier.urihttps://doi.org/10.4328/JCAM.1632
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2380
dc.identifier.volume5en_US
dc.identifier.wosWOS:000215569100019
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherJournal of Clinical and Analytical Medicineen_US
dc.relation.ispartofJournal of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInjection painen_US
dc.subjectLidocaineen_US
dc.subjectParacetamolen_US
dc.subjectRocuroniumen_US
dc.titleEffect of paracetamol pretreatment on rocuronium-induced injection pain: A randomized, double-blind, placebo-controlled comparison with lidocaineen_US
dc.title.alternativeParasetamol Ön Tedavisinin Roküromyumla İndüklenen Enjeksiyon Ağrısına Etkisien_US
dc.typeArticle

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