eNOS and iNOS trigger apoptosis in the brains of sheep and goats naturally infected with the border disease virus

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dc.contributor.authorDincel, Gungor Cagdas
dc.contributor.authorKul, Oguz
dc.date.accessioned2020-06-25T18:12:46Z
dc.date.available2020-06-25T18:12:46Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionDINCEL, Gungor Cagdas/0000-0002-6985-3197
dc.description.abstractIn this study, apoptotic and anti-apoptotic mechanisms and if present, which pathway to trigger the apoptosis in the brains of Border Disease Virus (BDV) infected lambs (n=10) and goat kids (n=5) were investigated. Briefly, apoptotic (caspase 3, caspase 9) and anti-apoptotic markers (Bcl-2), cytokine response (TNF-alpha, INF-gamma), reactive gliosis and myelin loss were examined. eNOS, iNOS, caspase 9, caspase 3 and GFAP expressions were higher in BDV infected tissues compared to control animals (6 kids and 6 lambs) (p<0.05). Double immunoperoxidase test revelaed that TUNEL positive apoptotic cells showed significant association with increased eNOS-iNOS and iNOS-BDV expressions. However, no significant differences were found for TNFR1, TNF-alpha and INF-gamma expressions in BD (p>0.05). There was a positive correlation between the intensity of myelin loss, GFAP activity and severity of infection. Inconclusion, as a novel finding, it is established that eNOS and iNOS overexpressions are co-associated with apoptosis in BDV infected neurons and neuroglia. The results also strongly suggested that BDV infected apoptotic cells mainly prefer the intrinsic pathway that might be most likely related to increased nitric oxide levels.en_US
dc.description.sponsorshipScientific Research Projects Commission of the Kirikkale University, Kirikkale, TurkeyKirikkale University [2011/37]en_US
dc.description.sponsorshipThis study was funded and supported by the Scientific Research Projects Commission of the Kirikkale University, Kirikkale, Turkey (Project Code: 2011/37). This manuscript is summarized from Kirikkale University, Institute of Health Sciences Ph.D thesis. In addition, this study was presented as an oral presentation in XXVII World Congress 2012, Lisbon, Portugal. We like to thank Dr. Monika Hilbe (Institute of Veterinary Pathology, Vetsuisse Faculty University of Zurich) for critical reading.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage1242en_US
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.issue10en_US
dc.identifier.pmid25882134
dc.identifier.scopus2-s2.0-84934347459
dc.identifier.scopusqualityQ2
dc.identifier.startpage1233en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6036
dc.identifier.volume30en_US
dc.identifier.wosWOS:000366337600010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherF Hernandezen_US
dc.relation.ispartofHistology And Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectBorder diseaseen_US
dc.subjecteNOSen_US
dc.subjectiNOSen_US
dc.titleeNOS and iNOS trigger apoptosis in the brains of sheep and goats naturally infected with the border disease virusen_US
dc.typeArticle

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