Effect of Carnitine on Cutaneous Wound Healing in Immunosuppressed Rats

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dc.contributor.authorAkkuş, Abdullah
dc.contributor.authorAydınuraz, Kuzey
dc.contributor.authorDaphan, Çağatay
dc.contributor.authorSaygun, Oral
dc.contributor.authorçağlayan, Osman
dc.contributor.authorEdremitlioğlu, Mustafa
dc.contributor.authorAğalar, Fatih
dc.date.accessioned2020-06-25T17:48:20Z
dc.date.available2020-06-25T17:48:20Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description5th Turkish Congress on Trauma and Emergency Surgery -- NOV 16-20, 2005 -- Antalya, TURKEY
dc.description.abstractBackground. The wound is ischemic in nature. Chronic steroid administration impairs wound healing by changing enzymes in the glycolytic pathway. Carnitine supplementation may help to restore the energy deficiency caused by chronic steroid administration in the wound. The aim of this study was to evaluate the effect of carnitine on impaired wound healing. Methods. The study was conducted in three groups. Surgical intervention was a 4 cm long midline skin incision at the back. In Group A, eight rats received methylprednisolone for 7 d prior to surgical intervention, and it was continued until the end of the experiment. In Group B, 12 rats received methylprednisolone for 7 d prior to surgical intervention. After surgery, methylprednisolone injection was continued and carnitine was supplemented until the end of the experiment. In Group C, eight rats received no medication. The wound of half of the animals in each group was harvested on the seventh day after surgical intervention and the remaining on the 14th d. Tensile strength and hydroxyproline content were measured in all groups. Results. There was no significant difference in parameters in any of the groups on day seven. On day 14, all parameters were statistically different between methylprednisolone and control groups (P < 0.05). Values for tensile strength were higher in the methylprednisolone/carnitine group compared with methylprednisolone group (P < 0.05). Carnitine administration had also increased hydroxyproline levels in the methylprednisolone/carnitine group compared with the control group (P < 0.05). Conclusions. Carnitine is shown to increase tensile strength of the wound when supplemented to immunosuppressed rats in which wound healing is impaired by methylprednisolone. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jss.2008.06.010
dc.identifier.endpage305en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid19505698
dc.identifier.scopus2-s2.0-67650973675
dc.identifier.scopusqualityQ1
dc.identifier.startpage301en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2008.06.010
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4410
dc.identifier.volume155en_US
dc.identifier.wosWOS:000269332300018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal Of Surgical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcarnitineen_US
dc.subjectimmunosuppressionen_US
dc.subjectwound healingen_US
dc.titleEffect of Carnitine on Cutaneous Wound Healing in Immunosuppressed Ratsen_US
dc.typeArticle

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