Caustic esophageal injury decreases the number of interstitial cells of Cajal in the rat esophagus
Yükleniyor...
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tubitak Scientific & Technical Research Council Turkey
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: To evaluate the effect of caustic esophageal injury (CEI) on the number of interstitial cells of Cajal (ICC) Materials and methods: Wistar rats were divided into 3 groups. control, acid, and alkali induced CEI CEI was performed by the injection of 1 mL of 10% hypochloric acid in the acid group, and 1 mL of 10% sodium hydroxide was injected into the alkali group. Distal esophageal segments were removed 24 h after injection CEI was graded and the number of ICC were investigated (CD-117 staining) The number of ICC was compared in groups and correlated with CEI grades Results: Typical histopathologic features of CEI were encountered in acid (mean grade 0 25 +/- 0.15), and in alkali (median 2, range. 1 25-3) groups The number of ICC was decreased in both the acid (mean 12 8 +/- 9.2) and alkali (median 2, range 0.0-4 0) groups with respect to the control group (mean 30 5 +/- 6 5) (P < 0 05) In addition, alkali group had a decreased number of ICC, when compared to the acid group (P < 0 05) Histopathologic grading showed an inverse correlation with number of ICC in both the acid (rs: 0 678) and alkali (rs 0.759) groups Conclusion: CEI decreases the number of ICC in the rat esophagus. Alkali caustics cause a higher grade of esophageal injury and a greater decrease in the number of ICC Motility disorders after caustic ingestion may be related to the decreased number of ICC
Açıklama
Soyer, Tutku/0000-0003-1505-6042
Anahtar Kelimeler
Caustic esophageal injury, interstitial cells of Cajal, esophagus
Kaynak
Turkish Journal Of Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
40
Sayı
4
Künye
Soyer, T., Ayva, Ş., Somuncu, S., Atasoy, P., Kanmaz, T., Çakmak, M. (2010). Caustic esophageal injury decreases the number of interstitial cells of Cajal in the rat esophagus. Turkish Journal of Medical Sciences, 40(4), 599 - 604.
