Caustic esophageal injury decreases the number of interstitial cells of Cajal in the rat esophagus

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dc.contributor.authorSoyer, Tutku
dc.contributor.authorAyva, Sebnem
dc.contributor.authorSomuncu, Salih
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorKanmaz, Turan
dc.contributor.authorCakmak, Murat
dc.date.accessioned2020-06-25T17:49:23Z
dc.date.available2020-06-25T17:49:23Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionSoyer, Tutku/0000-0003-1505-6042
dc.description.abstractAim: To evaluate the effect of caustic esophageal injury (CEI) on the number of interstitial cells of Cajal (ICC) Materials and methods: Wistar rats were divided into 3 groups. control, acid, and alkali induced CEI CEI was performed by the injection of 1 mL of 10% hypochloric acid in the acid group, and 1 mL of 10% sodium hydroxide was injected into the alkali group. Distal esophageal segments were removed 24 h after injection CEI was graded and the number of ICC were investigated (CD-117 staining) The number of ICC was compared in groups and correlated with CEI grades Results: Typical histopathologic features of CEI were encountered in acid (mean grade 0 25 +/- 0.15), and in alkali (median 2, range. 1 25-3) groups The number of ICC was decreased in both the acid (mean 12 8 +/- 9.2) and alkali (median 2, range 0.0-4 0) groups with respect to the control group (mean 30 5 +/- 6 5) (P < 0 05) In addition, alkali group had a decreased number of ICC, when compared to the acid group (P < 0 05) Histopathologic grading showed an inverse correlation with number of ICC in both the acid (rs: 0 678) and alkali (rs 0.759) groups Conclusion: CEI decreases the number of ICC in the rat esophagus. Alkali caustics cause a higher grade of esophageal injury and a greater decrease in the number of ICC Motility disorders after caustic ingestion may be related to the decreased number of ICCen_US
dc.identifier.citationSoyer, T., Ayva, Ş., Somuncu, S., Atasoy, P., Kanmaz, T., Çakmak, M. (2010). Caustic esophageal injury decreases the number of interstitial cells of Cajal in the rat esophagus. Turkish Journal of Medical Sciences, 40(4), 599 - 604.en_US
dc.identifier.doi10.3906/sag-0809-9
dc.identifier.endpage604en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-77955862771
dc.identifier.scopusqualityQ1
dc.identifier.startpage599en_US
dc.identifier.trdizinid106512
dc.identifier.urihttps://doi.org/10.3906/sag-0809-9
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4705
dc.identifier.volume40en_US
dc.identifier.wosWOS:000281832100013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaustic esophageal injuryen_US
dc.subjectinterstitial cells of Cajalen_US
dc.subjectesophagusen_US
dc.titleCaustic esophageal injury decreases the number of interstitial cells of Cajal in the rat esophagusen_US
dc.typeArticle

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