Does Generalized Linear Model Support Functional Default Mode Network Studies

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dc.contributor.authorKocak, Orhan Murat
dc.contributor.authorOzdemir Rezaki, Hatice
dc.contributor.authorTurkel, Yakup
dc.contributor.authorInal, Mikail
dc.contributor.authorButurak, Sadiye Visal
dc.date.accessioned2020-06-25T18:30:18Z
dc.date.available2020-06-25T18:30:18Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction: A growing body of research has emerged on the resting state and the default mode of the brain. Functional connectivity studies, which lately dominate this research area, have confirmed that regions such as the cortical mid-line structures, as well as parietal-temporal regions are tightly interconnected within the default mode network (DMN). However, little is known about the activity patterns of resting state related brain regions detected in fMRI studies using the generalized linear model (GLM) in a whole brain analysis. The aim of the current study was to investigate the activity changes among brain regions identified through GLM during the transition from task to rest and the prolongation of rest. Methods: A picture imagination task, as a controlled thought content task, was used in order to minimize confounding factors such as a visual stimulus or a motor response. Results: The present study revealed a consistent fluctuating activation pattern of the dorsal anterior cingulate cortex (dACC), the posterior cingulate cortex (PCC), thalamus, primer motor area (PMA), insula, brain stem and bilateral putamen during the transition from task to the early phase of the resting state and the prolongation of the resting state. All regions showed increased activation during the detachment from task. However, this increased activation was not sustained during the extension of rest, replaced with a decreased activation at the late phase of rest. The increased activation of resting state regions might help with the detachment from the current task. Among these regions dACC, insula and putamen were correlated in all conditions. Conclusion: These findings underline the importance of the activation increase of the cortical mid-line regions and insula in the transition from task to the resting state.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of the University of Kirikkale [2014/100]en_US
dc.description.sponsorshipThis study was supported by a grant from the Scientific Research Project Coordination Unit of the University of Kirikkale (2014/100).en_US
dc.identifier.citationKoçak OM, Rezakı HÖ, Türkel Y, İnal M, Visal Buturak Ş. Does Generalized Linear Model Support Functional Default Mode Network Studies. Noro Psikiyatr Ars. 2019 Oct 4;56(4):277-282.en_US
dc.identifier.doi10.29399/npa.23422
dc.identifier.endpage282en_US
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue4en_US
dc.identifier.pmid31903037
dc.identifier.scopus2-s2.0-85078266938
dc.identifier.scopusqualityQ3
dc.identifier.startpage277en_US
dc.identifier.trdizinid355323
dc.identifier.urihttps://doi.org/10.29399/npa.23422
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7610
dc.identifier.volume56en_US
dc.identifier.wosWOS:000510207600010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAvesen_US
dc.relation.ispartofNoropsikiyatri Arsivi-Archives Of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDefault mode networken_US
dc.subjectmind wanderingen_US
dc.subjectcortical mid-line structuresen_US
dc.subjectGLMen_US
dc.titleDoes Generalized Linear Model Support Functional Default Mode Network Studiesen_US
dc.typeArticle

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