Impact of adiponectin on left ventricular mass index in non-complicated obese subjects

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dc.contributor.authorEbinc, Haksun
dc.contributor.authorEbninc, Fatma Ayerden
dc.contributor.authorOezkurt, Zuebeyde Nur
dc.contributor.authorDogru, Mehmet Tolga
dc.contributor.authorTulmac, Murat
dc.contributor.authorYilmaz, Murat
dc.contributor.authorCaglayan, Osman
dc.date.accessioned2020-06-25T17:44:34Z
dc.date.available2020-06-25T17:44:34Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.description.abstractTo evaluate the relationship between the adiponectin levels and left ventricular mass index (LVMI) in uncomplicated obese subjects. Fifty-nine subjects were assigned to the obese (BMI >= 30 kg/ml) and 58 to the lean (BMI<30 kg/m(2)) group. Plasma glucose, insulin, serum total cholesterol and high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides and adiponectin were measured. Insulin resistance was determined by the Homeostasis Assessment Model (HOMA-IR). The left ventricular functions of all subjects were determined by 2D and pulse wave Doppler echocardiography. LVMI was calculated as left ventricular mass (LVM) normalized for height in M-2.7. The obese group displayed significantly higher LVMI and late mitral inflow velocity. Thirty-three obese subjects met the criteria for left ventricular hypertrophy (LVH) and had lower serum adiponectin levels compared with obese subjects without LVH and lean subjects (p<0.05). Adiponectin was negatively correlated with LVMI (R: -0.277, p: 0.002). Furthermore, during the partial correlation analysis where HOMA-IR was controlled, the negative correlation between adiponectin and LVMI progressed (r: -0.283, p: 0.002). The linear regression analysis showed an independent relationship between LVMI and adiponectin. (beta: -0.214, p: 0.01) Obesity is associated with LVH. This study showed direct influence of adiponectin on LVMI.en_US
dc.identifier.citationEbinç, H., Ebinç, F. A., Ozkurt, Z. N., Doğru, M. T., Tulmaç, M., Yilmaz, M., & Cağlayan, O. (2008). Impact of adiponectin on left ventricular mass index in non-complicated obese subjects. Endocrine journal, 55(3), 523–528.en_US
dc.identifier.doi10.1507/endocrj.K07E-098
dc.identifier.endpage528en_US
dc.identifier.issn0918-8959
dc.identifier.issue3en_US
dc.identifier.pmid18469485
dc.identifier.scopus2-s2.0-46749104513
dc.identifier.scopusqualityQ3
dc.identifier.startpage523en_US
dc.identifier.urihttps://doi.org/10.1507/endocrj.K07E-098
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4142
dc.identifier.volume55en_US
dc.identifier.wosWOS:000257343200012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJapan Endocrine Socen_US
dc.relation.ispartofEndocrine Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectadiponectinen_US
dc.subjectleft ventricular mass indexen_US
dc.subjectobesityen_US
dc.subjectechocardiographyen_US
dc.titleImpact of adiponectin on left ventricular mass index in non-complicated obese subjectsen_US
dc.typeArticle

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