A rat model of polypropylene graft infection caused by Staphylococcus epidermidis

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dc.contributor.authorAğalar, Canan
dc.contributor.authorÖzdoğan, Mehmet
dc.contributor.authorAğalar, Fatih
dc.contributor.authorSaygun, Oral
dc.contributor.authorAydınuraz, Kuzey
dc.contributor.authorAkkuş, Abdullah
dc.contributor.authorAktürk, Selçuk
dc.date.accessioned2020-06-25T17:43:33Z
dc.date.available2020-06-25T17:43:33Z
dc.date.issued2006
dc.description.abstractBackground: The aim of this study was to constitute a valid graft infection model with Staphylococcus epidermidis in rats. Method: Rats were divided into seven groups. In groups 1 and 2, 2 cm x 2 cm polypropylene grafts were incubated with 10(8) c.f.u./mL slime-positive S. epidermidis at 37 degrees C for 2 and 24 h and were then placed subfascially to the groins of rats. In the third group, naive grafts were placed and 0.5 mL of 3 x 10(7) c.f.u. slime-positive S. epidermidis were injected on the inside of the wounds. Rifampicin (30 mg/kg) in group 4 and teicoplanin (20 mg/kg) in group 5 were applied i.p. to rats with 2-h incubated grafts for prophylaxis. The same prophylactic regimens were given to groups 6 and 7 in which rats were incubated for 24 h. At eighth day, rats were killed and wounds were assessed with macroscopic evaluation and cultures. Results: No death occurred in any of the groups. In groups 1 and 2, 100% infection rates were achieved. However, graft infection was detected in only two (20%) of the rats in group 3 (P = 0.001). Prophylactic application of teicoplanin or rifampicin decreased the infection rates significantly in the short-incubation groups. Conclusion: Incubation of polypropylene grafts with slime-producing S. epidermidis for 2 and 24 h in the pre-application period achieved the occurrence of a standardized graft infection. Prophylactic use of teicoplanin and rifampicin decreased the infection rates. We propose to use this reproducible and reliable animal model of graft infection in future studies.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1445-2197.2006.03728.x
dc.identifier.endpage391en_US
dc.identifier.issn1445-1433
dc.identifier.issue5en_US
dc.identifier.pmid16768701
dc.identifier.scopus2-s2.0-33744771982
dc.identifier.scopusqualityQ2
dc.identifier.startpage387en_US
dc.identifier.urihttps://doi.org10.1111/j.1445-2197.2006.03728.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3791
dc.identifier.volume76en_US
dc.identifier.wosWOS:000237738500023
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofAnz Journal Of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectforeign body infectionen_US
dc.subjectgraften_US
dc.subjectherniaen_US
dc.subjectpolypropyleneen_US
dc.subjectStaphylococcus epidermidisen_US
dc.titleA rat model of polypropylene graft infection caused by Staphylococcus epidermidisen_US
dc.typeArticle

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