Hepatic stellate cells increase in Toxoplasma gondii infection in mice

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dc.contributor.authorAtmaca, Hasan Tarik
dc.contributor.authorGazyagci, Aycan Nuriye
dc.contributor.authorCanpolat, Sila
dc.contributor.authorKul, Oguz
dc.date.accessioned2020-06-25T18:07:17Z
dc.date.available2020-06-25T18:07:17Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionATMACA, HASAN TARIK/0000-0001-8379-4114
dc.description.abstractBackground: Toxoplasma gondii is a ubiquitous protozoan parasite that can infect humans and animals. The severity of toxoplasmosis varies according to the immune status of the individual, parasite strain, and host species. In mammalian species, it has been observed that severe lesions of acute toxoplasmosis form in visceral organs such as the liver, lung, and spleen. Some epidemiological studies have reported an association of T. gondii infection with liver cirrhosis. Methods: Acute infection was induced in fifteen 30-day-old normal Swiss albino mice. The mice were infected by intraperitoneal inoculation of 5000 T. gondii RH strain tachyzoites. The mice were sacrificed in groups of 5 at 2, 4, and 6 days after inoculation. Another group of 5 mice were used as the controls. Anti-glial fibrillary acidic protein (GFAP) and anti-T. gondii antibodies were used to compare GFAP-immunoreactive cells and anti-T. gondiiimmunopositive areas in the liver between the T. gondii-infected groups and the healthy controls, respectively. Results: There was a significant correlation between the numbers of GFAP-positive hepatic stellate cells (HSCs) when they were compared with T. gondii antigen immunostaining (p < 0.05). The amount of T. gondii immunostaining increased significantly with the increase in the number of HSCs. Conclusions: There is a significant relationship between the number of HSCs and T. gondii antigens, which may represent an active role of HSCs in liver pathology and the pathobiology of T. gondii-related hepatitis.en_US
dc.identifier.citationAtmaca, H.T., Gazyagcı, A.N., Canpolat, S. et al. Hepatic stellate cells increase in Toxoplasma gondii infection in mice. Parasites Vectors 6, 135 (2013).en_US
dc.identifier.doi10.1186/1756-3305-6-135
dc.identifier.issn1756-3305
dc.identifier.pmid23642259
dc.identifier.scopus2-s2.0-84876992772
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/1756-3305-6-135
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5534
dc.identifier.volume6en_US
dc.identifier.wosWOS:000319162700003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmcen_US
dc.relation.ispartofParasites & Vectors
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectToxoplasma gondiien_US
dc.subjectLiveren_US
dc.subjectHepatic stellate cellen_US
dc.subjectHepatitisen_US
dc.subjectAcuteen_US
dc.titleHepatic stellate cells increase in Toxoplasma gondii infection in miceen_US
dc.typeArticle

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