Severe Myelotoxicity Associated with Thiopurine S-Methyltransferase*3A/*3C Polymorphisms in a Patient with Pediatric Leukemia and the Effect of Steroid Therapy

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dc.contributor.authorBelen, Burcu Fatma
dc.contributor.authorGursel, Turkiz
dc.contributor.authorAkyurek, Nalan
dc.contributor.authorAlbayrak, Meryem
dc.contributor.authorKaya, Zuhre
dc.contributor.authorKocak, Ulker
dc.date.accessioned2020-06-25T18:07:54Z
dc.date.available2020-06-25T18:07:54Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractMyelosuppression is a serious complication during treatment of acute lymphoblastic leukemia and the duration of myelosuppression is affected by underlying bone marrow failure syndromes and drug pharmacogenetics caused by genetic polymorphisms. Mutations in the thiopurine S-methyltransferase (TPMT) gene causing excessive myelosuppression during 6-mercaptopurine (MP) therapy may cause excessive bone marrow toxicity. We report the case of a 15-year-old girl with T-ALL who developed severe pancytopenia during consolidation and maintenance therapy despite reduction of the dose of MP to 5% of the standard dose. Prednisolone therapy produced a remarkable but transient bone marrow recovery. Analysis of common TPMT polymorphisms revealed TPMT *3A/*3C.en_US
dc.identifier.citationBurcu Fatma Belen, Turkız Gursel, Nalan Akyurek, Meryem Albayrak, Zühre Kaya, Ülker Kocak. Severe Myelotoxicity Associated with Thiopurine S-Methyltransferase*3A/*3C Polymorphisms in a Patient with Pediatric Leukemia and the Effect of Steroid Therapy. Turk J Hematol. 2014; 31(4): 399-402.en_US
dc.identifier.doi10.4274/tjh.2013.0082
dc.identifier.endpage402en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue4en_US
dc.identifier.pmid25541649
dc.identifier.scopus2-s2.0-84924530899
dc.identifier.scopusqualityQ3
dc.identifier.startpage399en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.2013.0082
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5686
dc.identifier.volume31en_US
dc.identifier.wosWOS:000348688800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal Of Hematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMyelosuppressionen_US
dc.subjectThiopurine S-methyl transferaseen_US
dc.subjectAcute leukemiaen_US
dc.titleSevere Myelotoxicity Associated with Thiopurine S-Methyltransferase*3A/*3C Polymorphisms in a Patient with Pediatric Leukemia and the Effect of Steroid Therapyen_US
dc.typeArticle

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